Brain, Vol 121, Issue 5 889-905, Copyright © 1998 by Oxford University Press
A Bailey, P Luthert, A Dean, B Harding, I Janota, M Montgomery, M Rutter and P Lantos
A neuropathological study of autism was established and brain tissue
examined from six mentally handicapped subjects with autism. Clinical and
educational records were obtained and standardized diagnostic interviews
conducted with the parents of cases not seen before death. Four of the six
brains were megalencephalic, and areas of cortical abnormality were
identified in four cases. There were also developmental abnormalities of
the brainstem, particularly of the inferior olives. Purkinje cell number
was reduced in all the adult cases, and this reduction was sometimes
accompanied by gliosis. The findings do not support previous claims of
localized neurodevelopmental abnormalities. They do point to the likely
involvement of the cerebral cortex in autism.
ARTICLES
A clinicopathological study of autism
MRC Child Psychiatry Unit, Institute of Psychiatry, London, UK.
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