Brain, Vol 121, Issue 5 949-965, Copyright © 1998 by Oxford University Press
AM Owen, J Doyon, A Dagher, A Sadikot and AC Evans
In this study we examined the effects of striatal dopamine depletion on
cortical and subcortical blood flow changes during two tasks known to
involve frontostriatal circuitry. Regional cerebral blood flow was measured
in six patients with moderate Parkinson's disease and in six age-matched
control subjects while they performed easy and difficult versions of a
modified Tower of London planning task and a mnemonic variant of this task
that required short-term retention and reproduction of problem solutions,
as well as a control condition that involved identical visual stimuli and
motor responses. Relative to control conditions, the planning task was
associated with an increase in cerebral blood flow centred on the internal
segment of the right globus pallidus in the age-matched control subjects,
and a decrease in the same region in the patients with Parkinson's disease.
A similar inverse relationship between the task-specific blood flow change
observed in the control group and that observed in the Parkinson's disease
patients was not found in any other subcortical or cortical area examined,
including regions of the dorsolateral frontal cortex known to be involved
in this task. When blood flow in the spatial working memory task was
examined, a similarly specific dissociation between the two groups of
subjects was observed at similar coordinates in the right pallidum. We
conclude that striatal dopamine depletion disrupts the normal pattern of
basal ganglia outflow in Parkinson's disease and consequently, affects the
expression of frontal-lobe functions by interrupting normal transmission of
information through frontostriatal circuitry.
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Abnormal basal ganglia outflow in Parkinson's disease identified with PET. Implications for higher cortical functions
MRC Applied Psychology Unit, Cambridge, UK.
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