Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (245)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Springer, J. A.
Right arrow Articles by Mueller, W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Springer, J. A.
Right arrow Articles by Mueller, W. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 122, No. 11, 2033-2046, November 1999
© 1999 Oxford University Press

Invited review

Language dominance in neurologically normal and epilepsy subjects

A functional MRI study

Jane A. Springer1, Jeffrey R. Binder2,3, Thomas A. Hammeke2, Sara J. Swanson2, Julie A. Frost2, Patrick S. F. Bellgowan2, Cameron C. Brewer6, Holly M. Perry5, George L. Morris2 and Wade M. Mueller4

1 University of Iowa Hospital and Clinics, Iowa City, Departments of 2 Neurology, 3 Cellular Biology and Anatomy and 4 Neurosurgery, Medical College of Wisconsin, 5 Department of Psychology, Marquette University, Milwaukee, USA and 6 Department of Psychology, University of Scotland, Glasgow, UK

Correspondence to: Jeffrey R. Binder, MD, Department of Neurology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA E-mail: jbinder{at}post.its.mcw.edu

Language dominance and factors that influence language lateralization were investigated in right-handed, neurologically normal subjects (n = 100) and right-handed epilepsy patients (n = 50) using functional MRI. Increases in blood oxygenation-dependent signal during a semantic language activation task relative to a non-linguistic, auditory discrimination task provided an index of language system lateralization. As expected, the majority of both groups showed left hemisphere dominance, although a continuum of activation asymmetry was evident, with nearly all subjects showing some degree of right hemisphere activation. Using a categorical dominance classification, 94% of the normal subjects were considered left hemisphere dominant and 6% had bilateral, roughly symmetric language representation. None of the normal subjects had rightward dominance. There was greater variability of language dominance in the epilepsy group, with 78% showing left hemisphere dominance, 16% showing a symmetric pattern and 6% showing right hemisphere dominance. Atypical language dominance in the epilepsy group was associated with an earlier age of brain injury and with weaker right hand dominance. Language lateralization in the normal group was weakly related to age, but was not significantly related to sex, education, task performance or familial left-handedness.

cerebral dominance; language; functional MRI; lateralization

EHI = Edinburgh Handedness Inventory; fMRI = functional MRI; IAP = intracarotid amobarbital procedure; LI = laterality index


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
M. S. Koyama, C. Kelly, Z. Shehzad, D. Penesetti, F. X. Castellanos, and M. P. Milham
Reading Networks at Rest
Cereb Cortex, February 5, 2010; (2010) bhq005v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T. Duning, C. Kellinghaus, S. Mohammadi, H. Schiffbauer, S. Keller, E B. Ringelstein, S. Knecht, and M. Deppe
Individual white matter fractional anisotropy analysis on patients with MRI negative partial epilepsy
J. Neurol. Neurosurg. Psychiatry, February 1, 2010; 81(2): 136 - 139.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. E. Warren, J. T. Crinion, M. A. Lambon Ralph, and R. J. S. Wise
Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke
Brain, December 1, 2009; 132(12): 3428 - 3442.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Gartus, T. Foki, A. Geissler, and R. Beisteiner
Improvement of Clinical Language Localization with an Overt Semantic and Syntactic Language Functional MR Imaging Paradigm
AJNR Am. J. Neuroradiol., November 1, 2009; 30(10): 1977 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
L. R. Rosenberger, J. Zeck, M. M. Berl, E. N. Moore, E. K. Ritzl, S. Shamim, S. L. Weinstein, J. A. Conry, P. L. Pearl, S. Sato, et al.
Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy
Neurology, May 26, 2009; 72(21): 1830 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. Vannest, P. R. Karunanayaka, V. J. Schmithorst, J. P. Szaflarski, and S. K. Holland
Language Networks in Children: Evidence from Functional MRI Studies
Am. J. Roentgenol., May 1, 2009; 192(5): 1190 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Mbwana, M. M. Berl, E. K. Ritzl, L. Rosenberger, J. Mayo, S. Weinstein, J. A. Conry, P. L. Pearl, S. Shamim, E. N. Moore, et al.
Limitations to plasticity of language network reorganization in localization related epilepsy
Brain, February 1, 2009; 132(2): 347 - 356.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. Hagura, Y. Oouchida, Y. Aramaki, T. Okada, M. Matsumura, N. Sadato, and E. Naito
Visuokinesthetic Perception of Hand Movement is Mediated by Cerebro-Cerebellar Interaction between the Left Cerebellum and Right Parietal Cortex
Cereb Cortex, January 1, 2009; 19(1): 176 - 186.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Josse, M. L. Seghier, F. Kherif, and C. J. Price
Explaining Function with Anatomy: Language Lateralization and Corpus Callosum Size
J. Neurosci., December 24, 2008; 28(52): 14132 - 14139.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. Ottman, L. Rosenberger, A. Bagic, K. Kamberakis, E. K. Ritzl, A. M. Wohlschlager, S. Shamim, S. Sato, C. Liew, W. D. Gaillard, et al.
Altered language processing in autosomal dominant partial epilepsy with auditory features
Neurology, December 9, 2008; 71(24): 1973 - 1980.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
I. E. C. Sommer, K. M. J. Diederen, J.-D. Blom, A. Willems, L. Kushan, K. Slotema, M. P. M. Boks, K. Daalman, H. W. Hoek, S. F. W. Neggers, et al.
Auditory verbal hallucinations predominantly activate the right inferior frontal area
Brain, December 1, 2008; 131(12): 3169 - 3177.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
E. S. O'Shaughnessy, M. M. Berl, E. N. Moore, and W. D. Gaillard
Pediatric Functional Magnetic Resonance Imaging (fMRI): Issues and Applications
J Child Neurol, July 1, 2008; 23(7): 791 - 801.
[Abstract] [PDF]

Home page
 NeurologyHome page
I. Derakhshan, W. D. Gaillard, and W. H. Theodore
ATYPICAL LANGUAGE IN LESIONAL AND NONLESIONAL COMPLEX PARTIAL EPILEPSY
Neurology, June 3, 2008; 70(23): 2266 - 2267.
[Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
H W R Powell, G J M Parker, D C Alexander, M R Symms, P A Boulby, G J Barker, P J Thompson, M J Koepp, and J. S Duncan
Imaging language pathways predicts postoperative naming deficits
J. Neurol. Neurosurg. Psychiatry, March 1, 2008; 79(3): 327 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
I.M. Ruff, N.M. Petrovich Brennan, K.K. Peck, B.L. Hou, V. Tabar, C.W. Brennan, and A.I. Holodny
Assessment of the Language Laterality Index in Patients with Brain Tumor Using Functional MR Imaging: Effects of Thresholding, Task Selection, and Prior Surgery
AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 528 - 535.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, M. M. Berl, E. N. Moore, E. K. Ritzl, L. R. Rosenberger, S. L. Weinstein, J. A. Conry, P. L. Pearl, F. F. Ritter, S. Sato, et al.
Atypical language in lesional and nonlesional complex partial epilepsy
Neurology, October 30, 2007; 69(18): 1761 - 1771.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Sveller, R. S. Briellmann, M. M. Saling, L. Lillywhite, D. F. Abbott, R.A.J. Masterton, and G. D. Jackson
Relationship between language lateralization and handedness in left-hemispheric partial epilepsy
Neurology, November 28, 2006; 67(10): 1813 - 1817.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Jefferies and M. A. Lambon Ralph
Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison
Brain, August 1, 2006; 129(8): 2132 - 2147.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. L. Isaacs, W. B. Barr, P. K. Nelson, and O. Devinsky
Degree of handedness and cerebral dominance
Neurology, June 27, 2006; 66(12): 1855 - 1858.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
G.S. Harrington, M.H. Buonocore, and S. T. Farias
Intrasubject reproducibility of functional MR imaging activation in language tasks.
AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 938 - 944.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. P. Richardson, B. A. Strange, J. S. Duncan, and R. J. Dolan
Memory fMRI in left hippocampal sclerosis: Optimizing the approach to predicting postsurgical memory
Neurology, March 14, 2006; 66(5): 699 - 705.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
N. L. Voets, J. E. Adcock, D. E. Flitney, T. E. J. Behrens, Y. Hart, R. Stacey, K. Carpenter, and P. M. Matthews
Distinct right frontal lobe activation in language processing following left hemisphere injury
Brain, March 1, 2006; 129(3): 754 - 766.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. Weber, J. Wellmer, M. Reuber, F. Mormann, S. Weis, H. Urbach, J. Ruhlmann, C. E. Elger, and G. Fernandez
Left hippocampal pathology is associated with atypical language lateralization in patients with focal epilepsy
Brain, February 1, 2006; 129(2): 346 - 351.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. M. Berl, L. M. Balsamo, B. Xu, E. N. Moore, S. L. Weinstein, J. A. Conry, P. L. Pearl, B. C. Sachs, C. B. Grandin, C. Frattali, et al.
Seizure focus affects regional language networks assessed by fMRI
Neurology, November 22, 2005; 65(10): 1604 - 1611.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Bartha, T Benke, G Bauer, and E Trinka
Interictal language functions in temporal lobe epilepsy
J. Neurol. Neurosurg. Psychiatry, June 1, 2005; 76(6): 808 - 814.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Naito, P. E. Roland, C. Grefkes, H. J. Choi, S. Eickhoff, S. Geyer, K. Zilles, and H. H. Ehrsson
Dominance of the Right Hemisphere and Role of Area 2 in Human Kinesthesia
J Neurophysiol, February 1, 2005; 93(2): 1020 - 1034.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J.-F. Demonet, G. Thierry, and D. Cardebat
Renewal of the Neurophysiology of Language: Functional Neuroimaging
Physiol Rev, January 1, 2005; 85(1): 49 - 95.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Anneken, C. Konrad, B. Drager, C. Breitenstein, I. Kennerknecht, E. B. Ringelstein, and S. Knecht
Familial aggregation of strong hemispheric language lateralization
Neurology, December 28, 2004; 63(12): 2433 - 2435.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. Janszky, I. Ollech, H. Jokeit, K. Kontopoulou, M. Mertens, B. Pohlmann-Eden, A. Ebner, and F. G. Woermann
Epileptic activity influences the lateralization of mesiotemporal fMRI activity
Neurology, November 23, 2004; 63(10): 1813 - 1817.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. P. Richardson, B. A. Strange, P. J. Thompson, S. A. Baxendale, J. S. Duncan, and R. J. Dolan
Pre-operative verbal memory fMRI predicts post-operative memory decline after left temporal lobe resection
Brain, November 1, 2004; 127(11): 2419 - 2426.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, L. Balsamo, B. Xu, C. McKinney, P. H. Papero, S. Weinstein, J. Conry, P. L. Pearl, B. Sachs, S. Sato, et al.
fMRI language task panel improves determination of language dominance
Neurology, October 26, 2004; 63(8): 1403 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
I. E. C. Sommer, A. Aleman, A. Bouma, and R. S. Kahn
Do women really have more bilateral language representation than men? A meta-analysis of functional imaging studies
Brain, August 1, 2004; 127(8): 1845 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. Liegeois, A. Connelly, J. H. Cross, S. G. Boyd, D. G. Gadian, F. Vargha-Khadem, and T. Baldeweg
Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
Brain, June 1, 2004; 127(6): 1229 - 1236.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. T. Devlin, J. Raley, E. Tunbridge, K. Lanary, A. Floyer-Lea, C. Narain, I. Cohen, T. Behrens, P. Jezzard, P. M. Matthews, et al.
Functional Asymmetry for Auditory Processing in Human Primary Auditory Cortex
J. Neurosci., December 17, 2003; 23(37): 11516 - 11522.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
F. G. Woermann, H. Jokeit, R. Luerding, H. Freitag, R. Schulz, S. Guertler, M. Okujava, P. Wolf, I. Tuxhorn, and A. Ebner
Language lateralization by Wada test and fMRI in 100 patients with epilepsy
Neurology, September 9, 2003; 61(5): 699 - 701.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Janszky, H. Jokeit, D. Heinemann, R. Schulz, F. G. Woermann, and A. Ebner
Epileptic activity influences the speech organization in medial temporal lobe epilepsy
Brain, September 1, 2003; 126(9): 2043 - 2051.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D.S. Sabsevitz, S.J. Swanson, T. A. Hammeke, M. V. Spanaki, E. T. Possing, G. L. Morris III, W. M. Mueller, and J. R. Binder
Use of preoperative functional neuroimaging to predict language deficits from epilepsy surgery
Neurology, June 10, 2003; 60(11): 1788 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
Z. Ahmad, L. M. Balsamo, B. C. Sachs, B. Xu, and W. D. Gaillard
Auditory comprehension of language in young children: Neural networks identified with fMRI
Neurology, May 27, 2003; 60(10): 1598 - 1605.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. T. Crinion, M. A. Lambon-Ralph, E. A. Warburton, D. Howard, and R. J. S. Wise
Temporal lobe regions engaged during normal speech comprehension
Brain, May 1, 2003; 126(5): 1193 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
M. P Richardson
Epilepsy and surgical mapping
Br. Med. Bull., March 1, 2003; 65(1): 179 - 192.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. Usui, A. Ikeda, M. Takayama, M. Matsuhashi, J.-I. Yamamoto, T. Satoh, T. Begum, N. Mikuni, J. B. Takahashi, S. Miyamoto, et al.
Conversion of semantic information into phonological representation: a function in left posterior basal temporal area
Brain, March 1, 2003; 126(3): 632 - 641.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Krainik, S. Lehericy, H. Duffau, L. Capelle, H. Chainay, P. Cornu, L. Cohen, A. -L. Boch, J. -F. Mangin, D. Le Bihan, et al.
Postoperative speech disorder after medial frontal surgery: Role of the supplementary motor area
Neurology, February 25, 2003; 60(4): 587 - 594.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W.D. Gaillard, L.M. Balsamo, Z. Ibrahim, B.C. Sachs, and B. Xu
fMRI identifies regional specialization of neural networks for reading in young children
Neurology, January 14, 2003; 60(1): 94 - 100.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. W.L. Chee and D. Caplan
Face encoding and psychometric testing in healthy dextrals with right hemisphere language
Neurology, December 24, 2002; 59(12): 1928 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
D. P. Anderson, A. S. Harvey, M. M. Saling, V. Anderson, M. Kean, R. Jacobs, D. F. Abbott, R. M. Wellard, A. Puce, and G. Jackson
Differential Functional Magnetic Resonance Imaging Language Activation in Twins Discordant for a Left Frontal Tumor
J Child Neurol, October 1, 2002; 17(10): 766 - 769.
[Abstract] [PDF]

Home page
 NeurologyHome page
J. P. Szaflarski, J. R. Binder, E. T. Possing, K. A. McKiernan, B. D. Ward, and T. A. Hammeke
Language lateralization in left-handed and ambidextrous people: fMRI data
Neurology, July 23, 2002; 59(2): 238 - 244.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, L. Balsamo, B. Xu, C. B. Grandin, S. H. Braniecki, P. H. Papero, S. Weinstein, J. Conry, P. L. Pearl, B. Sachs, et al.
Language dominance in partial epilepsy patients identified with an fMRI reading task
Neurology, July 23, 2002; 59(2): 256 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
L. M. Balsamo, B. Xu, C. B. Grandin, J. R. Petrella, S. H. Braniecki, T. K. Elliott, and W. D. Gaillard
A Functional Magnetic Resonance Imaging Study of Left Hemisphere Language Dominance in Children
Arch Neurol, July 1, 2002; 59(7): 1168 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Lehericy, A. Biondi, N. Sourour, M. Vlaicu, S. T. du Montcel, L. Cohen, E. Vivas, L. Capelle, T. Faillot, A. Casasco, et al.
Arteriovenous Brain Malformations: Is Functional MR Imaging Reliable for Studying Language Reorganization in Patients? Initial Observations
Radiology, June 1, 2002; 223(3): 672 - 682.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. Hertz-Pannier, C. Chiron, I. Jambaque, V. Renaux-Kieffer, P.-F. V. d. Moortele, O. Delalande, M. Fohlen, F. Brunelle, and D. L. Bihan
Late plasticity for language in a child's non-dominant hemisphere: A pre- and post-surgery fMRI study
Brain, February 1, 2002; 125(2): 361 - 372.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. S. McLachlan, A. Venneri, M. F. Shanks, and D. P. Carey
Preservation of golf skills in a case of severe left lobar frontotemporal degeneration
Neurology, January 22, 2002; 58(2): 331 - 332.
[Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, M. Pugliese, C. B. Grandin, S. H. Braniecki, P. Kondapaneni, K. Hunter, B. Xu, J. R. Petrella, L. Balsamo, and G. Basso
Cortical localization of reading in normal children: An fMRI language study
Neurology, July 10, 2001; 57(1): 47 - 54.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Staudt, W. Grodd, G. Niemann, D. Wildgruber, M. Erb, and I. Krageloh-Mann
Early left periventricular brain lesions induce right hemispheric organization of speech
Neurology, July 10, 2001; 57(1): 122 - 125.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. L. Billingsley, M. P. McAndrews, A. P. Crawley, and D. J. Mikulis
Functional MRI of phonological and semantic processing in temporal lobe epilepsy
Brain, June 1, 2001; 124(6): 1218 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
J. A. Detre and T. F. Floyd
Functional MRI and Its Applications to the Clinical Neurosciences
Neuroscientist, February 1, 2001; 7(1): 64 - 79.
[Abstract] [PDF]

Home page
 BrainHome page
S. Knecht, B. Drager, M. Deppe, L. Bobe, H. Lohmann, A. Floel, E.-B. Ringelstein, and H. Henningsen
Handedness and hemispheric language dominance in healthy humans
Brain, December 1, 2000; 123(12): 2512 - 2518.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
W. D. Gaillard and W. H. Theodore
Mapping Language in Epilepsy with Functional Imaging
Neuroscientist, October 1, 2000; 6(5): 390 - 400.
[Abstract] [PDF]

Home page
 JWatch NeurologyHome page
fMRI Useful in Determining Language Dominance
Journal Watch Neurology, February 1, 2000; 2000(201): 16 - 16.
[Full Text]

Home page
 BrainHome page
A. Gjedde
Gradients of the brain
Brain, November 1, 1999; 122(11): 2013 - 2014.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.