Brain, Vol. 122, No. 3, 483-495,
March 1999
© 1999 Oxford University Press
Article |
A PET study of sequential finger movements of varying length in patients with Parkinson's disease
1 Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA and 2 Servicio de Neurologia, Hospital Universitario San Carlos, Madrid, Spain
Correspondence to:
Mark Hallett, MD, Clinical Director, NINDS, NIH, Building 10, Room 5N226, 10 Center Drive MSC 1428, Bethesda, MD 20892-1428, USA E-mail: hallett{at}codon.nih.gov
To study the difficulty that patients with Parkinson's disease have in performing long sequential movements, we used H215O PET to assess the regional cerebral blood flow (rCBF) associated with the performance of simple repetitive movements, well-learned sequential finger movements of varying length and self-selected movements. Sequential finger movements in the Parkinson's disease patients were associated with an activation pattern similar to that found in normal subjects, but Parkinson's disease patients showed relative overactivity in the precuneus, premotor and parietal cortices. Increasing the complexity of movements resulted in increased rCBF in the premotor and parietal cortices of normal subjects; the Parkinson's disease patients showed greater increases in these same regions and had additional significant increases in the anterior supplementary motor area (SMA)/cingulate. Performance of self-selected movements induced significant activation of the anterior SMA/cingulate in normal subjects but not in Parkinson's disease patients. We conclude that in Parkinson's disease patients more cortical areas are recruited to perform sequential finger movements; this may be the result of increasing corticocortical activity to compensate for striatal dysfunction.
Parkinson's disease; SMA; parietal; premotor; PET
BA = Brodmann area; rCBF = regional cerebral blood flow; SMA = supplementary motor area
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