Brain, Vol. 122, No. 7, 1327-1340,
July 1999
© 1999 Oxford University Press
Corticomotoneuronal synaptic connections in normal man
An electrophysiological study
University Department of Neurology, Hôpital de la Citadelle, Liège, Belgium
Correspondence to:
Alain Maertens de Noordhout, MD, University Department of Neurology, Hôpital de la Citadelle, Boulevard du XIIème de Ligne, 1, B-4000 Liège, Belgium E-mail: al.maertens{at}chu.ulg.ac.be
In order to determine the mono- or oligosynaptic character of connections between pyramidal axons and individual spinal motor neurons, we constructed peri-stimulus time histograms (PSTHs) of the firing probability of voluntarily activated single motor units (SMUs) of various upper and lower limb muscles upon slightly suprathreshold transcranial anodal electrical stimulations of the motor cortex in normal subjects. Weak anodal cortical stimuli are known to activate preferentially fast-conducting pyramidal axons directly, bypassing cell bodies and cortical interneurons. A narrow bin width (0.1 ms) was chosen to measure precisely the duration of the PSTH excitatory peak, which corresponds to the rise time of the underlying compound excitatory post-synaptic potentials (EPSP). A short duration PSTH peak indicates sharp-rising EPSPs, most commonly encountered in the case of monosynaptic connections. In flexor carpi radialis and soleus SMUs, the PSTHs of built-in responses to anodal cortical stimuli were compared with those produced by 1A afferent stimulation able to elicit a Hoffmann reflex, which is known to be largely monosynaptic. In all upper and lower limb muscles, excitable SMUs responded to anodal cortical stimuli with a highly synchronized peak of increased firing probability. In flexor carpi radialis and soleus SMUs, the mean duration of this peak was significantly narrower than that evoked by 1A afferent stimulation, indicating that monosynaptic corticomotor neuronal transmission dominates low-threshold motor units, even in proximal arm and leg muscles. In the various muscles studied, and particularly in forearm SMUs, we did not observe broad PSTH peaks against the activation of non-monosynaptic corticomotor neuronal pathways, even with near-threshold stimuli. In some triceps and forearm flexor SMUs, subthreshold anodal pulses caused significant inhibition of their voluntary firing, with a latency consistent with activation of 1A inhibitory interneurons by the descending volleys. Measurements of the maximal number of counts in the excitatory PSTH peak upon anodal cortical stimuli provide comparisons of the strength of monosynaptic inputs to various muscles which seems to be maximal for hand and finger extensor muscles, and also for deltoid.
corticospinal tract; motor neurons; motor cortex stimulation
EPSP = excitatory post-synaptic potential; H-reflex = Hoffmann reflex; PSTH = peri-stimulus time histograms; PTN = pyramidal tract neurons; SMU = single motor unit; TCS = transcranial anodal electrical stimulations; TMS = transcranial magnetic stimulation
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