Brain, Vol. 123, No. 11, 2306-2313,
November 2000
© 2000 Oxford University Press
Neural representations of skilled movement
1 Psychology and Research Services, Veterans Affairs Medical Center and Departments of Neurology and Psychology and 2 Department of Psychiatry, University of New Mexico, Albuquerque, and 3 Department of Psychology, University of California, Berkeley, California, USA
Correspondence to:
Katheen Y. Haaland, Psychology Service (116B), Veterans Affairs Medical Center, 1501 San Pedro SE, Albuquerque, NM 87108, USA E-mail: khaaland{at}unm.edu
The frontal and parietal cortex are intimately involved in the representation of goal-directed movements, but the crucial neuroanatomical sites are not well established in humans. In order to identify these sites more precisely, we studied stroke patients who had the classic syndrome of ideomotor limb apraxia, which disrupts goal-directed movements, such as writing or brushing teeth. Patients with and without limb apraxia were identified by assessing errors imitating gestures and specifying a cut-off for apraxia relative to a normal control group. We then used MRI or CT for lesion localization and compared areas of overlap in those patients with and without limb apraxia. Patients with ideomotor limb apraxia had damage lateralized to a left hemispheric network involving the middle frontal gyrus and intraparietal sulcus region. Thus, the results revealed that discrete areas in the left hemisphere of humans are critical for control of complex goal-directed movements.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Dromey and E. Shim The Effects of Divided Attention on Speech Motor, Verbal Fluency, and Manual Task Performance J Speech Lang Hear Res, October 1, 2008; 51(5): 1171 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bohlhalter, N. Hattori, L. Wheaton, E. Fridman, E. A. Shamim, G. Garraux, and M. Hallett Gesture Subtype-Dependent Left Lateralization of Praxis Planning: An Event-Related fMRI Study Cereb Cortex, September 16, 2008; (2008) bhn168v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Langan and P. van Donkelaar The Influence of Hand Dominance on the Response to a Constraint-Induced Therapy Program Following Stroke Neurorehabil Neural Repair, June 1, 2008; 22(3): 298 - 304. [Abstract] [PDF]
|
|
|
|
|
|
A. F. de C. Hamilton and S. T. Grafton Action Outcomes Are Represented in Human Inferior Frontoparietal Cortex Cereb Cortex, May 1, 2008; 18(5): 1160 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Canessa, F. Borgo, S. F. Cappa, D. Perani, A. Falini, G. Buccino, M. Tettamanti, and T. Shallice The Different Neural Correlates of Action and Functional Knowledge in Semantic Memory: An fMRI Study Cereb Cortex, April 1, 2008; 18(4): 740 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pazzaglia, N. Smania, E. Corato, and S. M. Aglioti Neural Underpinnings of Gesture Discrimination in Patients with Limb Apraxia J. Neurosci., March 19, 2008; 28(12): 3030 - 3041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Weiss, N. N. Rahbari, M. D. Hesse, and G. R. Fink Deficient sequencing of pantomimes in apraxia Neurology, March 11, 2008; 70(11): 834 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Goldenberg, J. Hermsdorfer, R. Glindemann, C. Rorden, and H.-O. Karnath Pantomime of Tool Use Depends on Integrity of Left Inferior Frontal Cortex Cereb Cortex, December 1, 2007; 17(12): 2769 - 2776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Kaas, H. van Mier, and R. Goebel The Neural Correlates of Human Working Memory for Haptically Explored Object Orientations Cereb Cortex, July 1, 2007; 17(7): 1637 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tessari, N. Canessa, M. Ukmar, and R. I. Rumiati Neuropsychological evidence for a strategic control of multiple routes in imitation Brain, April 1, 2007; 130(4): 1111 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Weisberg, M. van Turennout, and A. Martin A Neural System for Learning about Object Function Cereb Cortex, March 1, 2007; 17(3): 513 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Wheaton Parietal Representations for Hand-Object Interactions J. Neurosci., January 31, 2007; 27(5): 969 - 970. [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Jax, L. J. Buxbaum, and A. D. Moll Deficits in Movement Planning and Intrinsic Coordinate Control in Ideomotor Apraxia J. Cogn. Neurosci., December 1, 2006; 18(12): 2063 - 2076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Diedrichsen, S. Grafton, N. Albert, E. Hazeltine, and R. B. Ivry Goal-Selection and Movement-Related Conflict during Bimanual Reaching Movements Cereb Cortex, December 1, 2006; 16(12): 1729 - 1738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Carroll, R. D. Herbert, J. Munn, M. Lee, and S. C. Gandevia Contralateral effects of unilateral strength training: evidence and possible mechanisms J Appl Physiol, November 1, 2006; 101(5): 1514 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Aramaki, M. Honda, T. Okada, and N. Sadato Neural Correlates of the Spontaneous Phase Transition during Bimanual Coordination Cereb Cortex, September 1, 2006; 16(9): 1338 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gentilucci, P. Bernardis, G. Crisi, and R. D. Volta Repetitive Transcranial Magnetic Stimulation of Broca's Area Affects Verbal Responses to Gesture Observation. J. Cogn. Neurosci., July 1, 2006; 18(7): 1059 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Goldenberg and H.-O. Karnath The neural basis of imitation is body part specific. J. Neurosci., June 7, 2006; 26(23): 6282 - 6287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Lewis Cortical Networks Related to Human Use of Tools Neuroscientist, June 1, 2006; 12(3): 211 - 231. [Abstract] [PDF]
|
|
|
|
|
|
P. Raghavan, J. W. Krakauer, and A. M. Gordon Impaired anticipatory control of fingertip forces in patients with a pure motor or sensorimotor lacunar syndrome Brain, June 1, 2006; 129(6): 1415 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Naito and H. H. Ehrsson Somatic sensation of hand-object interactive movement is associated with activity in the left inferior parietal cortex. J. Neurosci., April 5, 2006; 26(14): 3783 - 3790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Grol, F. P. de Lange, F. A. J. Verstraten, R. E. Passingham, and I. Toni Cerebral Changes during Performance of Overlearned Arbitrary Visuomotor Associations J. Neurosci., January 4, 2006; 26(1): 117 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Johnson-Frey, R. Newman-Norlund, and S. T. Grafton A Distributed Left Hemisphere Network Active During Planning of Everyday Tool Use Skills Cereb Cortex, June 1, 2005; 15(6): 681 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Makuuchi Is Broca's Area Crucial for Imitation? Cereb Cortex, May 1, 2005; 15(5): 563 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Makuuchi, T Kaminaga, and M Sugishita Brain activation during ideomotor praxis: imitation and movements executed by verbal command J. Neurol. Neurosurg. Psychiatry, January 1, 2005; 76(1): 25 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Haaland, C. L. Elsinger, A. R. Mayer, S. Durgerian, and S. M. Rao Motor Sequence Complexity and Performing Hand Produce Differential Patterns of Hemispheric Lateralization J. Cogn. Neurosci., May 1, 2004; 16(4): 621 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Haaland, J. L. Prestopnik, R. T. Knight, and R. R. Lee Hemispheric asymmetries for kinematic and positional aspects of reaching Brain, May 1, 2004; 127(5): 1145 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Garry, G. Kamen, and M. A. Nordstrom Hemispheric Differences in the Relationship Between Corticomotor Excitability Changes Following a Fine-Motor Task and Motor Learning J Neurophysiol, April 1, 2004; 91(4): 1570 - 1578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Korn, W. Reith, and G. Becker Impaired Volitional Closure of the Left Eyelid After Right Anterior Cerebral Artery Infarction: Apraxia Due to Interhemispheric Disconnection? Arch Neurol, February 1, 2004; 61(2): 273 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. MacDonald and T. Paus The Role of Parietal Cortex in Awareness of Self-generated Movements: a Transcranial Magnetic Stimulation Study Cereb Cortex, September 1, 2003; 13(9): 962 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gerlach, I. Law, and O. B. Paulson When Action Turns into Words. Activation of Motor-Based Knowledge during Categorization of Manipulable Objects J. Cogn. Neurosci., November 1, 2002; 14(8): 1230 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Goldenberg and S. Strauss Hemisphere asymmetries for imitation of novel gestures Neurology, September 24, 2002; 59(6): 893 - 897. [Abstract] [Full Text] [PDF]
|
|