Brain, Vol. 123, No. 12, 2400-2406,
December 2000
© 2000 Oxford University Press
Identification of a pathway for intelligible speech in the left temporal lobe
1 Institute of Cognitive Neuroscience and 2 Department of Phonetics and Linguistics, University College London, 3 MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London, UK
Correspondence to:
Sophie K. Scott, Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK E-mail: sophie.scott{at}ucl.ac.uk
It has been proposed that the identification of sounds, including species-specific vocalizations, by primates depends on anterior projections from the primary auditory cortex, an auditory pathway analogous to the ventral route proposed for the visual identification of objects. We have identified a similar route in the human for understanding intelligible speech. Using PET imaging to identify separable neural subsystems within the human auditory cortex, we used a variety of speech and speech-like stimuli with equivalent acoustic complexity but varying intelligibility. We have demonstrated that the left superior temporal sulcus responds to the presence of phonetic information, but its anterior part only responds if the stimulus is also intelligible. This novel observation demonstrates a left anterior temporal pathway for speech comprehension.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Desai, E. Liebenthal, E. Waldron, and J. R. Binder Left Posterior Temporal Regions are Sensitive to Auditory Categorization. J. Cogn. Neurosci., July 1, 2008; 20(7): 1174 - 1188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Abrams, T. Nicol, S. Zecker, and N. Kraus Right-Hemisphere Auditory Cortex Is Dominant for Coding Syllable Patterns in Speech J. Neurosci., April 9, 2008; 28(15): 3958 - 3965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Upadhyay, A. Silver, T. A. Knaus, K. A. Lindgren, M. Ducros, D.-S. Kim, and H. Tager-Flusberg Effective and Structural Connectivity in the Human Auditory Cortex J. Neurosci., March 26, 2008; 28(13): 3341 - 3349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. OWEN Disorders of Consciousness Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 225 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Ischebeck, A. D. Friederici, and K. Alter Processing Prosodic Boundaries in Natural and Hummed Speech: An fMRI Study Cereb Cortex, March 1, 2008; 18(3): 541 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Noppeney, O. Josephs, J. Hocking, C. J. Price, and K. J. Friston The Effect of Prior Visual Information on Recognition of Speech and Sounds Cereb Cortex, March 1, 2008; 18(3): 598 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Campbell, M. MacSweeney, and D. Waters Sign Language and the Brain: A Review J. Deaf Stud. Deaf Educ., January 1, 2008; 13(1): 3 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Coez, M. Zilbovicius, E. Ferrary, D. Bouccara, I. Mosnier, E. Ambert-Dahan, E. Bizaguet, A. Syrota, Y. Samson, and O. Sterkers Cochlear Implant Benefits in Deafness Rehabilitation: PET Study of Temporal Voice Activations J. Nucl. Med., January 1, 2008; 49(1): 60 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Wilson, I. Molnar-Szakacs, and M. Iacoboni Beyond Superior Temporal Cortex: Intersubject Correlations in Narrative Speech Comprehension Cereb Cortex, January 1, 2008; 18(1): 230 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Abutalebi, S. M. Brambati, J.-M. Annoni, A. Moro, S. F. Cappa, and D. Perani The Neural Cost of the Auditory Perception of Language Switches: An Event-Related Functional Magnetic Resonance Imaging Study in Bilinguals J. Neurosci., December 12, 2007; 27(50): 13762 - 13769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Awad, J. E. Warren, S. K. Scott, F. E. Turkheimer, and R. J. S. Wise A Common System for the Comprehension and Production of Narrative Speech J. Neurosci., October 24, 2007; 27(43): 11455 - 11464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Davis, M. R. Coleman, A. R. Absalom, J. M. Rodd, I. S. Johnsrude, B. F. Matta, A. M. Owen, and D. K. Menon Dissociating speech perception and comprehension at reduced levels of awareness PNAS, October 9, 2007; 104(41): 16032 - 16037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Paul, K. Chawarska, C. Fowler, D. Cicchetti, and F. Volkmar "Listen My Children and You Shall Hear": Auditory Preferences in Toddlers With Autism Spectrum Disorders J Speech Lang Hear Res, October 1, 2007; 50(5): 1350 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Obleser, J. Zimmermann, J. Van Meter, and J. P. Rauschecker Multiple Stages of Auditory Speech Perception Reflected in Event-Related fMRI Cereb Cortex, October 1, 2007; 17(10): 2251 - 2257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Coleman, J. M. Rodd, M. H. Davis, I. S. Johnsrude, D. K. Menon, J. D. Pickard, and A. M. Owen Do vegetative patients retain aspects of language comprehension? Evidence from fMRI Brain, October 1, 2007; 130(10): 2494 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Joanisse, J. D. Zevin, and B. D. McCandliss Brain Mechanisms Implicated in the Preattentive Categorization of Speech Sounds Revealed Using fMRI and a Short-Interval Habituation Trial Paradigm Cereb Cortex, September 1, 2007; 17(9): 2084 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dick, A. P. Saygin, G. Galati, S. Pitzalis, S. Bentrovato, S. D'Amico, S. Wilson, E. Bates, and L. Pizzamiglio What is Involved and What is Necessary for Complex Linguistic and Nonlinguistic Auditory Processing: Evidence from Functional Magnetic Resonance Imaging and Lesion Data. J. Cogn. Neurosci., May 1, 2007; 19(5): 799 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Obleser, R. J. S. Wise, M. Alex Dresner, and S. K. Scott Functional Integration across Brain Regions Improves Speech Perception under Adverse Listening Conditions J. Neurosci., February 28, 2007; 27(9): 2283 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Warren, D. A. Sauter, F. Eisner, J. Wiland, M. A. Dresner, R. J. S. Wise, S. Rosen, and S. K. Scott Positive Emotions Preferentially Engage an Auditory-Motor "Mirror" System J. Neurosci., December 13, 2006; 26(50): 13067 - 13075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Kraut, J. A. Pitcock, V. Calhoun, J. Li, T. Freeman, and J. Hart Jr. Neuroanatomic organization of sound memory in humans. J. Cogn. Neurosci., November 1, 2006; 18(11): 1877 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Jamison, K. E. Watkins, D. V. M. Bishop, and P. M. Matthews Hemispheric Specialization for Processing Auditory Nonspeech Stimuli Cereb Cortex, September 1, 2006; 16(9): 1266 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Orfanidou, W. D. Marslen-Wilson, and M. H. Davis Neural response suppression predicts repetition priming of spoken words and pseudowords. J. Cogn. Neurosci., August 1, 2006; 18(8): 1237 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Obleser, S. K. Scott, and C. Eulitz Now You Hear It, Now You Don't: Transient Traces of Consonants and their Nonspeech Analogues in the Human Brain Cereb Cortex, August 1, 2006; 16(8): 1069 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Crinion, E. A. Warburton, M. A. Lambon-Ralph, D. Howard, and R. J.S. Wise Listening to Narrative Speech after Aphasic Stroke: the Role of the Left Anterior Temporal Lobe Cereb Cortex, August 1, 2006; 16(8): 1116 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Jefferies and M. A. Lambon Ralph Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison Brain, August 1, 2006; 129(8): 2132 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McNealy, J. C. Mazziotta, and M. Dapretto Cracking the language code: neural mechanisms underlying speech parsing. J. Neurosci., July 19, 2006; 26(29): 7629 - 7639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Spitsyna, J. E. Warren, S. K. Scott, F. E. Turkheimer, and R. J. S. Wise Converging language streams in the human temporal lobe. J. Neurosci., July 12, 2006; 26(28): 7328 - 7336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Devlin, H. L. Jamison, L. M. Gonnerman, and P. M. Matthews The role of the posterior fusiform gyrus in reading. J. Cogn. Neurosci., June 1, 2006; 18(6): 911 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Thierry and C. J. Price Dissociating verbal and nonverbal conceptual processing in the human brain. J. Cogn. Neurosci., June 1, 2006; 18(6): 1018 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Saur, R. Lange, A. Baumgaertner, V. Schraknepper, K. Willmes, M. Rijntjes, and C. Weiller Dynamics of language reorganization after stroke Brain, June 1, 2006; 129(6): 1371 - 1384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hauk, K. Patterson, A. Woollams, L. Watling, F. Pulvermuller, and T. T. Rogers [Q:] When would you prefer a SOSSAGE to a SAUSAGE? [A:] At about 100 msec. ERP correlates of orthographic typicality and lexicality in written word recognition. J. Cogn. Neurosci., May 1, 2006; 18(5): 818 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Humphries, J. R. Binder, D. A. Medler, and E. Liebenthal Syntactic and semantic modulation of neural activity during auditory sentence comprehension. J. Cogn. Neurosci., April 1, 2006; 18(4): 665 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Friederici, Jör. Bahlmann, S. Heim, R. I. Schubotz, and A. Anwander The brain differentiates human and non-human grammars: Functional localization and structural connectivity PNAS, February 14, 2006; 103(7): 2458 - 2463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Hunter, S. B. Eickhoff, T. W. R. Miller, T. F. D. Farrow, I. D. Wilkinson, and P. W. R. Woodruff Neural activity in speech-sensitive auditory cortex during silence PNAS, January 3, 2006; 103(1): 189 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inui, H. Okamoto, K. Miki, A. Gunji, and R. Kakigi Serial and Parallel Processing in the Human Auditory Cortex: A Magnetoencephalographic Study Cereb Cortex, January 1, 2006; 16(1): 18 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.M. Schulz, M. Varga, K. Jeffires, C.L. Ludlow, and A.R. Braun Functional Neuroanatomy of Human Vocalization: An H215O PET Study Cereb Cortex, December 1, 2005; 15(12): 1835 - 1847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Liebenthal, J. R. Binder, S. M. Spitzer, E. T. Possing, and D. A. Medler Neural Substrates of Phonemic Perception Cereb Cortex, October 1, 2005; 15(10): 1621 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. E. Cohen, B. E. Russ, and G. W. Gifford III Auditory processing in the posterior parietal cortex. Behav Cogn Neurosci Rev, September 1, 2005; 4(3): 218 - 231. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Rodd, M. H. Davis, and I. S. Johnsrude The Neural Mechanisms of Speech Comprehension: fMRI studies of Semantic Ambiguity Cereb Cortex, August 1, 2005; 15(8): 1261 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Miller and M. D'Esposito Perceptual Fusion and Stimulus Coincidence in the Cross-Modal Integration of Speech J. Neurosci., June 22, 2005; 25(25): 5884 - 5893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Boatman and D. L. Miglioretti Cortical Sites Critical for Speech Discrimination in Normal and Impaired Listeners J. Neurosci., June 8, 2005; 25(23): 5475 - 5480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Noppeney, C. J. Price, J. S. Duncan, and M. J. Koepp Reading skills after left anterior temporal lobe resection: an fMRI study Brain, June 1, 2005; 128(6): 1377 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Duffau, P. Gatignol, E. Mandonnet, P. Peruzzi, N. Tzourio-Mazoyer, and L. Capelle New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations Brain, April 1, 2005; 128(4): 797 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C.M. Bastiaansen, M. van der Linden, M. ter Keurs, T. Dijkstra, and P. Hagoort Theta Responses Are Involved in Lexical-Semantic Retrieval during Language Processing J. Cogn. Neurosci., March 1, 2005; 17(3): 530 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-F. Demonet, G. Thierry, and D. Cardebat Renewal of the Neurophysiology of Language: Functional Neuroimaging Physiol Rev, January 1, 2005; 85(1): 49 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. E. Cohen, B. E. Russ, G. W. Gifford III, R. Kiringoda, and K. A. MacLean Selectivity for the Spatial and Nonspatial Attributes of Auditory Stimuli in the Ventrolateral Prefrontal Cortex J. Neurosci., December 15, 2004; 24(50): 11307 - 11316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Tian and J. P. Rauschecker Processing of Frequency-Modulated Sounds in the Lateral Auditory Belt Cortex of the Rhesus Monkey J Neurophysiol, November 1, 2004; 92(5): 2993 - 3013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Fiebach, S. H. Vos, and A. D. Friederici Neural Correlates of Syntactic Ambiguity in Sentence Comprehension for Low and High Span Readers J. Cogn. Neurosci., November 1, 2004; 16(9): 1562 - 1575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Rauschecker and B. Tian Processing of Band-Passed Noise in the Lateral Auditory Belt Cortex of the Rhesus Monkey J Neurophysiol, June 1, 2004; 91(6): 2578 - 2589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Callan, J. A. Jones, K. Munhall, C. Kroos, A. M. Callan, and E. Vatikiotis-Bateson Multisensory Integration Sites Identified by Perception of Spatial Wavelet Filtered Visual Speech Gesture Information J. Cogn. Neurosci., June 1, 2004; 16(5): 805 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Marinkovic Spatiotemporal Dynamics of Word Processing in the Human Cortex Neuroscientist, April 1, 2004; 10(2): 142 - 152. [Abstract] [PDF]
|
|
|
|
|
|
D. J. Sharp, S. K. Scott, and R. J.S. Wise Monitoring and the Controlled Processing of Meaning: Distinct Prefrontal Systems Cereb Cortex, January 1, 2004; 14(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Devlin, J. Raley, E. Tunbridge, K. Lanary, A. Floyer-Lea, C. Narain, I. Cohen, T. Behrens, P. Jezzard, P. M. Matthews, et al. Functional Asymmetry for Auditory Processing in Human Primary Auditory Cortex J. Neurosci., December 17, 2003; 23(37): 11516 - 11522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Narain, S. K. Scott, R. J.S. Wise, S. Rosen, A. Leff, S.D. Iversen, and P.M. Matthews Defining a Left-lateralized Response Specific to Intelligible Speech Using fMRI Cereb Cortex, December 1, 2003; 13(12): 1362 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. WARREN, S. UPPENKAMP, R. D. PATTERSON, and T. D. GRIFFITHS Analyzing Pitch Chroma and Pitch Height in the Human Brain Ann. N.Y. Acad. Sci., November 1, 2003; 999(1): 212 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jacquemot, C. Pallier, D. LeBihan, S. Dehaene, and E. Dupoux Phonological Grammar Shapes the Auditory Cortex: A Functional Magnetic Resonance Imaging Study J. Neurosci., October 22, 2003; 23(29): 9541 - 9546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Fitch and P. Tallal Neural Mechanisms of Language-Based Learning Impairments: Insights from Human Populations and Animal Models Behav Cogn Neurosci Rev, September 1, 2003; 2(3): 155 - 178. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Warren, S. Uppenkamp, R. D. Patterson, and T. D. Griffiths Separating pitch chroma and pitch height in the human brain PNAS, August 19, 2003; 100(17): 10038 - 10042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Warren and T. D. Griffiths Distinct Mechanisms for Processing Spatial Sequences and Pitch Sequences in the Human Auditory Brain J. Neurosci., July 2, 2003; 23(13): 5799 - 5804. [Abstract] [Full Text] [PDF]
|
|
|
|