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Brain, Vol. 123, No. 12, 2531-2541, December 2000
© 2000 Oxford University Press

Neural consequences of acting in near versus far space: a physiological basis for clinical dissociations

Peter H. Weiss1,2, John C. Marshall4, Gilbert Wunderlich1,2, Lutz Tellmann1, Peter W. Halligan5, Hans-Joachim Freund2, Karl Zilles1,3 and Gereon R. Fink1,2

1 Institut für Medizin, Forschungszentrum Jülich, Jülich, 2 Neurologische Klinik and 3 C. and O. Vogt-Hirnforschungsinstitut, Heinrich-Heine-Universität, Düsseldorf, Germany, 4 Neuropsychology Unit, University Department of Clinical Neurology, Radcliffe Infirmary, Oxford and 5 School of Psychology, Cardiff University, Cardiff, UK

Correspondence to: Dr Gereon R. Fink, Institut für Medizin (IME), Forschungszentrum Jülich, 52425 Jülich, Germany E-mail: G.Fink{at}fz-juelich.de

We used PET to determine which brain regions are implicated when normal volunteers bisect horizontal lines and point to dots in near (peripersonal) or far (extrapersonal) space. Studies of line bisection in patients with right hemisphere lesions have shown that bisection performance can be severely impaired in either near or far space while remaining within normal limits in the other spatial domain. Likewise, clinical dissociations between pointing to objects in near and far space have been reported. The normal functional anatomy of these dissociations has not been demonstrated convincingly. Regional cerebral blood flow measurements using PET were carried out in 12 healthy right-handed male volunteers who bisected lines or pointed to dots in near or far space, using a laser pen. Subjects performing either task in near space showed neural activity in the left dorsal occipital cortex, left intraparietal cortex, left ventral premotor cortex and left thalamus. In far space, subjects performing either task showed activation of the ventral occipital cortex bilaterally and the right medial temporal cortex. These data provide physiological support for the clinically observed dissociations demonstrating that attending to and acting in near space differentially employs dorsal visuomotor processing areas, whereas attending to and acting in far space differentially draws on ventral visuoperceptual processing areas, even when the motor components of the tasks are identical when performed in the two spaces.


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