Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (86)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Rossor, M. N.
Right arrow Articles by Warrington, E. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rossor, M. N.
Right arrow Articles by Warrington, E. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 123, No. 2, 267-276, February 2000
© 2000 Oxford University Press

Semantic dementia with ubiquitin-positive tau-negative inclusion bodies

M. N. Rossor1, T. Revesz2, P. L. Lantos3 and Elizabeth K. Warrington1

1 Dementia Research Group, Department of Clinical Neurology, 2 Neuropathology Department, Institute of Neurology, 3 Department of Neuropathology, Instituteof Psychiatry, London, UK

Correspondence to: Professor M. N. Rossor, Dementia Research Group, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK

Three cases are reported with dementia and ubiquitin-positive but tau-negative inclusion bodies. All patients had a semantic dementia and the clinical details of two of these have been published as the first description of a selective semantic memory impairment. The original diagnosis had been of Pick's disease based on frontotemporal atrophy, but re-examination has revealed ubiquitin-positive but tau-negative inclusions as well as neurites in the frontotemporal cortices and ubiquitin-positive, intracytoplasmic inclusions in the granule cells of the dentate fascia. These inclusions are identical to those reported in association with amyotrophic lateral sclerosis (motor neuron disease), but none were seen in brainstem or spinal cord motor neurons.

semantic dementia; frontotemporal dementia; Pick's disease; frontotemporal degeneration; ubiquitin

WAIS = Wechsler Adult Intelligence Scale


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
K. Rascovsky, M. E. Growdon, I. R. Pardo, S. Grossman, and B. L. Miller
'The quicksand of forgetfulness': semantic dementia in One Hundred Years of Solitude
Brain, May 15, 2009; (2009) awp100v1.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
S. J. Banks and S. Weintraub
Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia
J Geriatr Psychiatry Neurol, June 1, 2008; 21(2): 133 - 141.
[Abstract] [PDF]

Home page
 BrainHome page
J. D. Rohrer, W. D. Knight, J. E. Warren, N. C. Fox, M. N. Rossor, and J. D. Warren
Word-finding difficulty: a clinical analysis of the progressive aphasias
Brain, January 1, 2008; 131(1): 8 - 38.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
J. A. Levy and G. J. Chelune
Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease
J Geriatr Psychiatry Neurol, December 1, 2007; 20(4): 227 - 238.
[Abstract] [PDF]

Home page
 BrainHome page
H. Seelaar, H. Jurgen Schelhaas, A. Azmani, B. Kusters, S. Rosso, D. Majoor-Krakauer, M. C. de Rijik, P. Rizzu, M. ten Brummelhuis, P. A. van Doorn, et al.
TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations
Brain, May 1, 2007; 130(5): 1375 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. A. Josephs, J. R. Duffy, E. A. Strand, J. L. Whitwell, K. F. Layton, J. E. Parisi, M. F. Hauser, R. J. Witte, B. F. Boeve, D. S. Knopman, et al.
Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech
Brain, June 1, 2006; 129(6): 1385 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. H. Bak, D. Yancopoulou, P. J. Nestor, J. H. Xuereb, M. G. Spillantini, F. Pulvermuller, and J. R. Hodges
Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing
Brain, February 1, 2006; 129(2): 321 - 332.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. Likeman, V. M. Anderson, J. M. Stevens, A. D. Waldman, A. K. Godbolt, C. Frost, M. N. Rossor, and N. C. Fox
Visual Assessment of Atrophy on Magnetic Resonance Imaging in the Diagnosis of Pathologically Confirmed Young-Onset Dementias
Arch Neurol, September 1, 2005; 62(9): 1410 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. R. Davies, J. R. Hodges, J. J. Kril, K. Patterson, G. M. Halliday, and J. H. Xuereb
The pathological basis of semantic dementia
Brain, September 1, 2005; 128(9): 1984 - 1995.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. K. Godbolt, K. A. Josephs, T. Revesz, E. K. Warrington, P. Lantos, A. King, N. C. Fox, S. Al Sarraj, J. Holton, L. Cipolotti, et al.
Sporadic and Familial Dementia With Ubiquitin-Positive Tau-Negative Inclusions: Clinical Features of One Histopathological Abnormality Underlying Frontotemporal Lobar Degeneration
Arch Neurol, July 1, 2005; 62(7): 1097 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Graham, R. Davies, J. Xuereb, G. Halliday, J. Kril, H. Creasey, K. Graham, and J. Hodges
Pathologically proven frontotemporal dementia presenting with severe amnesia
Brain, March 1, 2005; 128(3): 597 - 605.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. C. Paviour, A. J. Lees, K. A. Josephs, T. Ozawa, M. Ganguly, C. Strand, A. Godbolt, R. S. Howard, T. Revesz, and J. L. Holton
Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy
Brain, November 1, 2004; 127(11): 2441 - 2451.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
E L Sampson, J D Warren, and M N Rossor
Young onset dementia
Postgrad. Med. J., March 1, 2004; 80(941): 125 - 139.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T M Polvikoski, A Murray, P S Harper, and J W Neal
Familial motor neurone disease with dementia: phenotypic variation and cerebellar pathology
J. Neurol. Neurosurg. Psychiatry, November 1, 2003; 74(11): 1516 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. A. Lambon Ralph, K. Patterson, N. Graham, K. Dawson, and J. R. Hodges
Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer's disease: a cross-sectional and longitudinal study of 55 cases
Brain, November 1, 2003; 126(11): 2350 - 2362.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M.-M. Mesulam
Primary Progressive Aphasia -- A Language-Based Dementia
N. Engl. J. Med., October 16, 2003; 349(16): 1535 - 1542.
[Full Text] [PDF]

Home page
 BrainHome page
K. A. Josephs, J. L. Holton, M. N. Rossor, H. Braendgaard, T. Ozawa, N. C. Fox, R. C. Petersen, G. S. Pearl, M. Ganguly, P. Rosa, et al.
Neurofilament inclusion body disease: a new proteinopathy?
Brain, October 1, 2003; 126(10): 2291 - 2303.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. D. Kopelman
Disorders of memory
Brain, October 1, 2002; 125(10): 2152 - 2190.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Rascovsky, D. P. Salmon, G. J. Ho, D. Galasko, G. M. Peavy, L. A. Hansen, and L. J. Thal
Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD
Neurology, June 25, 2002; 58(12): 1801 - 1808.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. L. Lantos, N. J. Cairns, M. N. Khan, A. King, T. Revesz, J. C. Janssen, H. Morris, and M. N. Rossor
Neuropathologic variation in frontotemporal dementia due to the intronic tau 10+16 mutation
Neurology, April 23, 2002; 58(8): 1169 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
A. Kertesz and D. G. Munoz
Primary progressive aphasia: A review of the neourobiology of a common presentation of Pick complex
American Journal of Alzheimer's Disease and Other Dementias, January 1, 2002; 17(1): 30 - 36.
[Abstract] [PDF]

Home page
 NeurologyHome page
D. Chan, N. C. Fox, R. Jenkins, R. I. Scahill, W. R. Crum, and M. N. Rossor
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia
Neurology, November 27, 2001; 57(10): 1756 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
H. R. Morris, S. Al-Sarraj, C. Schwab, K. Gwinn-Hardy, J. Perez-Tur, N. W. Wood, J. Hardy, A. J. Lees, P. L. McGeer, S. E. Daniel, et al.
A clinical and pathological study of motor neurone disease on Guam
Brain, November 1, 2001; 124(11): 2215 - 2222.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. M. Rosso, W. Kamphorst, B. de Graaf, R. Willemsen, R. Ravid, M. F. Niermeijer, M. G. Spillantini, P. Heutink, and J. C. van Swieten
Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22
Brain, October 1, 2001; 124(10): 1948 - 1957.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. J. Galton, K. Patterson, K. Graham, M.A. Lambon-Ralph, G. Williams, N. Antoun, B.J. Sahakian, and J.R. Hodges
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia
Neurology, July 24, 2001; 57(2): 216 - 225.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
T. H. Bak, D. G. O'Donovan, J. H. Xuereb, S. Boniface, and J. R. Hodges
Selective impairment of verb processing associated with pathological changes in Brodmann areas 44 and 45 in the motor neurone disease-dementia-aphasia syndrome
Brain, January 1, 2001; 124(1): 103 - 120.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.