Brain, Vol. 123, No. 3, 425-462,
March 2000
© 2000 Oxford University Press
Invited review |
Tourette syndrome, associated conditions and the complexities of treatment
Department of Psychiatry and Behavioural Sciences, University College and The National Hospital for Neurology and Neurosurgery, London, UK
Correspondence to:
Professor Mary M. Robertson, Department of Psychiatry and Behavioural Sciences, University College London, 2nd Floor, Wolfson Building, 48 Riding House Street, London W1N 8AA, UK E-mail: rejummr{at}ucl.ac.uk
Tourette syndrome (TS) is characterized by multiple motor tics plus one or more vocal (phonic) tics, which characteristically wax and wane. It can no longer be considered the rare and bizarre syndrome that it was once thought to be. The concepts surrounding TS, and our understanding of it, are also becoming increasingly complex and, in some individuals, TS is now recognized to be associated with a wide variety of associated behaviours and psychopathologies. It is suggested that TS is heterogeneous from a variety of standpoints including clinical presentation and psychopathology, and thus neuropharmacological responses and possibly even aetiological and genetic mechanisms. In this paper, mention is made of recent findings in epidemiology and genetics, highlighting the complexities of the disorder; these have been chosen because findings in both areas have clinical and management implications. The literature on the clinical manifestations, associated behaviours, psychopathology (and/or comorbid conditions) and management, in particular, is reviewed in detail.
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