Brain, Vol. 124, No. 12, 2503-2512,
December 2001
© 2001 Oxford University Press
Mechanisms of cognitive set flexibility in Parkinson's disease
1 Department of Experimental Psychology, 2 Cambridge Centre for Brain Repair and Department of Neurology and 3 Department of Psychiatry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
Correspondence to:
Trevor W. Robbins, University of Cambridge, Department of Experimental Psychology, Downing Street, Cambridge CB3 9DF, UK E-mail: twr2{at}cam.ac.uk
Previous research on cognitive set shifting in patients with Parkinson's disease has often been confounded by concept formation, rule learning, working memory and/or general slowing of cognitive processes. To circumvent this problem, the present study used the task-set switching procedure in which good performance was independent of rule learning, and in which working memory load was reduced by explicitly cueing the task switches. Our results provide strong evidence for a specific cognitive set shifting deficit in patients with mild Parkinson's disease in a non-learning context, which also cannot be explained by general slowing of cognitive processes. Moreover, the deficit was robust in a small sample of patients at the earliest stages of the disease. Finally, the impairment in task-set switching was only apparent when competing information was present, i.e. when the load on selection mechanisms was increased.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Yehene, N. Meiran, and N. Soroker Basal Ganglia Play a Unique Role in Task Switching within the Frontal-Subcortical Circuits: Evidence from Patients with Focal Lesions. J. Cogn. Neurosci., June 1, 2008; 20(6): 1079 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nagano-Saito, M. Leyton, O. Monchi, Y. K. Goldberg, Y. He, and A. Dagher Dopamine Depletion Impairs Frontostriatal Functional Connectivity during a Set-Shifting Task J. Neurosci., April 2, 2008; 28(14): 3697 - 3706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, M. Sheridan, E. Jacobs, and M. D'Esposito Impulsive Personality Predicts Dopamine-Dependent Changes in Frontostriatal Activity during Component Processes of Working Memory J. Neurosci., May 16, 2007; 27(20): 5506 - 5514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rivaud-Pechoux, M. Vidailhet, J. P. Brandel, and B. Gaymard Mixing pro- and antisaccades in patients with parkinsonian syndromes Brain, January 1, 2007; 130(1): 256 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, R. B. Ivry, and M. D'Esposito The Human Striatum is Necessary for Responding to Changes in Stimulus Relevance J. Cogn. Neurosci., December 1, 2006; 18(12): 1973 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakamura and O. Hikosaka Role of dopamine in the primate caudate nucleus in reward modulation of saccades. J. Neurosci., May 17, 2006; 26(20): 5360 - 5369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Barber and C. S. Carter Cognitive Control Involved in Overcoming Prepotent Response Tendencies and Switching Between Tasks Cereb Cortex, July 1, 2005; 15(7): 899 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, L. Clark, and T. W. Robbins Differential Responses in Human Striatum and Prefrontal Cortex to Changes in Object and Rule Relevance J. Neurosci., February 4, 2004; 24(5): 1129 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Monchi, M. Petrides, J. Doyon, R. B. Postuma, K. Worsley, and A. Dagher Neural Bases of Set-Shifting Deficits in Parkinson's Disease J. Neurosci., January 21, 2004; 24(3): 702 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Marinus, M. Visser, N. A. Verwey, F. R.J. Verhey, H. A.M. Middelkoop, A. M. Stiggelbout, and J. J. van Hilten Assessment of cognition in Parkinson's disease Neurology, November 11, 2003; 61(9): 1222 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Aron, L. Watkins, B. J. Sahakian, S. Monsell, R. A. Barker, and T. W. Robbins Task-Set Switching Deficits in Early-Stage Huntington's Disease: Implications for Basal Ganglia Function J. Cogn. Neurosci., July 1, 2003; 15(5): 629 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Escola, Th. Michelet, F. Macia, D. Guehl, B. Bioulac, and P. Burbaud Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia? Brain, January 1, 2003; 126(1): 95 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Z Press, D J Mechanic, D Tarsy, and D S Manoach Cognitive slowing in Parkinson's disease resolves after practice J. Neurol. Neurosurg. Psychiatry, November 1, 2002; 73(5): 524 - 528. [Abstract] [Full Text] [PDF]
|
|