Brain, Vol. 124, No. 5, 1020-1032,
May 2001
© 2001 Oxford University Press
The role of the striatum and hippocampus in planning
A PET activation study in Parkinson's disease
1 MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, 2 Institute of Neurology, London, 3 MRC Cognition and Brain Sciences Unit, Cambridge, UK and 4 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada
Correspondence to:
Alain Dagher, MD, Montreal Neurological Institute, 3801 University Street, Montreal, Québec, Canada H3A 2B4 E-mail: alain@bic.mni.mcgill.ca
Previous work has identified the prefrontal cortex (PFC) and striatum as participating in the planning and selection of movements. We compared the brain activation patterns during planning in Parkinson's disease patients and age-matched controls using H215O-PET and the Tower of London (TOL) task. In this study, our mildly affected Parkinson's disease group performed as well as the control group but showed a different pattern of neuronal activation. In the two groups, overlapping areas of the PFC were activated but, whereas the right caudate nucleus was activated in the control group, this was not evident in the Parkinson's disease patients. This suggests that normal normal frontal lobe activation can occur in Parkinson's disease despite abnormal processing within the basal ganglia. Moreover, right hippocampus activity was suppressed in the controls and enhanced in the Parkinson's disease patients. This could represent a shift to the declarative memory system in Parkinson's disease during performance of the TOL task, possibly resulting from insufficient working memory capacity within the frontostriatal system.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. A. B. Wisman, G. Sahin, M. Maingay, G. Leanza, and D. Kirik Functional Convergence of Dopaminergic and Cholinergic Input Is Critical for Hippocampus-Dependent Working Memory J. Neurosci., July 30, 2008; 28(31): 7797 - 7807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sawamoto, P. Piccini, G. Hotton, N. Pavese, K. Thielemans, and D. J. Brooks Cognitive deficits and striato-frontal dopamine release in Parkinson's disease Brain, May 1, 2008; 131(5): 1294 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nagano-Saito, M. Leyton, O. Monchi, Y. K. Goldberg, Y. He, and A. Dagher Dopamine Depletion Impairs Frontostriatal Functional Connectivity during a Set-Shifting Task J. Neurosci., April 2, 2008; 28(14): 3697 - 3706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. D. Bohbot, J. Lerch, B. Thorndycraft, G. Iaria, and A. P. Zijdenbos Gray Matter Differences Correlate with Spontaneous Strategies in a Human Virtual Navigation Task J. Neurosci., September 19, 2007; 27(38): 10078 - 10083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A Boyd, E. D Vidoni, and J. J Daly Answering the Call: The Influence of Neuroimaging and Electrophysiological Evidence on Rehabilitation Physical Therapy, June 1, 2007; 87(6): 684 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Williams-Gray, A. Hampshire, T. W. Robbins, A. M. Owen, and R. A. Barker Catechol O-Methyltransferase val158met Genotype Influences Frontoparietal Activity during Planning in Patients with Parkinson's Disease J. Neurosci., May 2, 2007; 27(18): 4832 - 4838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sawamoto, M. Honda, T. Hanakawa, T. Aso, M. Inoue, H. Toyoda, K. Ishizu, H. Fukuyama, and H. Shibasaki Cognitive slowing in Parkinson disease is accompanied by hypofunctioning of the striatum Neurology, March 27, 2007; 68(13): 1062 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Monchi, M. Petrides, B. Mejia-Constain, and A. P. Strafella Cortical activity in Parkinson's disease during executive processing depends on striatal involvement Brain, January 1, 2007; 130(1): 233 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A L Cheesman, R A Barker, S J G Lewis, T W Robbins, A M Owen, and D J Brooks Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, September 1, 2005; 76(9): 1204 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nagano-Saito, Y. Washimi, Y. Arahata, T. Kachi, J. P. Lerch, A. C. Evans, A. Dagher, and K. Ito Cerebral atrophy and its relation to cognitive impairment in Parkinson disease Neurology, January 25, 2005; 64(2): 224 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Owen Cognitive Dysfunction in Parkinson's Disease: The Role of Frontostriatal Circuitry Neuroscientist, December 1, 2004; 10(6): 525 - 537. [Abstract] [PDF]
|
|
|
|
|
|
T. Foltynie, C. E. G. Brayne, T. W. Robbins, and R. A. Barker The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study Brain, March 1, 2004; 127(3): 550 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Monchi, M. Petrides, J. Doyon, R. B. Postuma, K. Worsley, and A. Dagher Neural Bases of Set-Shifting Deficits in Parkinson's Disease J. Neurosci., January 21, 2004; 24(3): 702 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. G. Lewis, A. Dove, T. W. Robbins, R. A. Barker, and A. M. Owen Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in Frontostriatal Neural Circuitry J. Neurosci., July 16, 2003; 23(15): 6351 - 6356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grossman, A. Cooke, C. DeVita, C. Lee, D. Alsop, J. Detre, J. Gee, W. Chen, M. B. Stern, and H. I. Hurtig Grammatical and resource components of sentence processing in Parkinson's disease: An fMRI study Neurology, March 11, 2003; 60(5): 775 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K R Turner, W G Reid, J Homewood, and R J Cook Neuropsychological sequelae of bilateral posteroventral pallidotomy J. Neurol. Neurosurg. Psychiatry, October 1, 2002; 73(4): 444 - 446. [Abstract] [Full Text] [PDF]
|
|