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Brain, Vol. 124, No. 6, 1182-1196, June 2001
© 2001 Oxford University Press

Cerebral representations for egocentric space

Functional–anatomical evidence from caloric vestibular stimulation and neck vibration

G. Bottini1,4, H.-O. Karnath7, G. Vallar2,5, R. Sterzi6, C. D. Frith8, R. S. J. Frackowiak8 and E. Paulesu2,3

1 Laboratorio di Neuropsicologia, Dipartimento di Scienze Neurologiche, Ospedale Niguarda cà Granda, 2 Dipartimento di Psicologia, Università degli Studi Milano-Bicocca, 3 INB-CNR; Scientific Institute H San Raffaele, Milano, 4 Sezione di Psicologia, Università degli Studi di Pavia, Pavia, 5 Fondazione S. Lucia, IRCCS, Roma, 6 Dipartimento di Neurologia, Ospedale Sant'anna, Como, Italy, 7 Department of Cognitive Neurology, Eberhard Karls University, Tübingen, Germany and 8 Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, UK

Correspondence to: G. Bottini, Sezione di Psicologia, Università degu studi di Pavia, Piazza Botta 6, 27100 Pavia, Italia. E-mail: g.bottini{at}unipv.it

The internal representation of space involves the integration of different sensory inputs—visual, somatosensory/proprioceptive, vestibular—yielding reference frames which are not based on individual peripheral sensory codes, being organized instead in ego-centred (e.g. head, trunk, arm) and object- or environment-centred coordinates. Lateralized or direction-specific stimulation of peripheral sensory systems, such as caloric vestibular stimulation (CVS), posterior neck muscle mechanical vibration (NV) and optokinetic stimulation, can induce a distortion of egocentric coordinates, causing, for example, a deviation of the subjective straight ahead in pointing tasks. Appropriate forms of this stimulation can also temporarily improve a variety of pathological manifestations of unilateral neglect. We used PET measurements of regional cerebral blood flow changes in normal volunteers to measure the brain responses shared by CVS and NV. We show that somatosensory areas of the perisylvian cortex including the insula and retroinsular cortex, the temporoparietal junction and somatosensory area II receive signals from both sensory channels. We propose that these anatomical sites contribute to egocentric representation of space.


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