Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (31)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Eliez, S.
Right arrow Articles by Reiss, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eliez, S.
Right arrow Articles by Reiss, A. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 124, No. 8, 1610-1618, August 2001
© 2001 Oxford University Press

Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome

Stephan Eliez1, Christine M. Blasey1, Lisa S. Freund3, Trevor Hastie2 and Allan L. Reiss1

1 Stanford Behavioral Neurogenetic Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 2 Department of Statistics, Stanford University and 3 National Institute of Child Health and Human Development, Rockville, Maryland, USA

Correspondence to: Stephan Eliez, MD, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305-5719, USA E-mail: eliez{at}stanford.edu

This study utilized MRI data to describe neuroanatomical morphology in children and adolescents with fragile X syndrome, the most common inherited cause of developmental disability. The syndrome provides a model for understanding how specific genetic factors can influence both neuroanatomy and cognitive capacity. Thirty-seven children and adolescents with fragile X syndrome received an MRI scan and cognitive testing. Scanning procedures and analytical strategies were identical to those reported in an earlier study of 85 typically developing children, permitting a comparison with a previously published template of normal brain development. Regression analyses indicated that there was a normative age-related decrease in grey matter and an increase in white matter. However, caudate and ventricular CSF volumes were significantly enlarged, and caudate volumes decreased with age. Rates of reduction of cortical grey matter were different for males and females. IQ scores were not significantly correlated with volumes of cortical and subcortical grey matter, and these relationships were statistically different from the correlational patterns observed in typically developing children. Children with fragile X syndrome exhibited several typical neurodevelopmental patterns. Aberrations in volumes of subcortical nuclei, gender differences in rates of cortical grey matter reduction and an absence of correlation between grey matter and cognitive performance provided indices of the deleterious effects of the fragile X mutation on the brain's structural organization.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Castren, T. Tervonen, V. Karkkainen, S. Heinonen, E. Castren, K. Larsson, C. E. Bakker, B. A. Oostra, and K. Akerman
Altered differentiation of neural stem cells in fragile X syndrome
PNAS, December 6, 2005; 102(49): 17834 - 17839.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. S. Kogan, I. Boutet, K. Cornish, S. Zangenehpour, K. T. Mullen, J. J. A. Holden, V. M. Der Kaloustian, E. Andermann, and A. Chaudhuri
Differential impact of the FMR1 gene on visual processing in fragile X syndrome
Brain, March 1, 2004; 127(3): 591 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. D. Bigler, D. F. Tate, E. S. Neeley, L. J. Wolfson, M. J. Miller, S. A. Rice, H. Cleavinger, C. Anderson, H. Coon, S. Ozonoff, et al.
Temporal Lobe, Autism, and Macrocephaly
AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 2066 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
W. E. Kaufmann, K. L. Cooper, S. H. Mostofsky, G. T. Capone, W. R. Kates, C. J. Newschaffer, I. Bukelis, M. H. Stump, A. E. Jann, and D. C. Lanham
Specificity of Cerebellar Vermian Abnormalities in Autism: A Quantitative Magnetic Resonance Imaging Study
J Child Neurol, July 1, 2003; 18(7): 463 - 470.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.