Brain, Vol. 125, No. 3, 584-594,
March 2002
© 2002 Guarantors of Brain
Dopaminergic modulation of high-level cognition in Parkinson’s disease: the role of the prefrontal cortex revealed by PET
1 Department of Experimental Psychology, University of Cambridge, Cambridge, 2 Cambridge Centre for Brain Repair and Department of Neurology, University of Cambridge, 3 MRC Cognition and Brain Sciences, Cambridge, UK and 4 Institute of Neurology, Dr Subotica 6, Belgrade, Yugoslavia
Correspondence to: Roshan Cools, C.D. Marsden Parkinson’s Disease Society Research Student, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK E-mail: rc245{at}cam.ac.uk
This study examined the effects of L-dopa medication in patients with Parkinson’s disease on cortical and subcortical blood flow changes during two tasks known to involve frontostriatal circuitry. Eleven patients with Parkinson’s disease were scanned on two occasions, one ON L-dopa medication and one OFF L-dopa medication, during performance of the Tower of London planning task and a related test that emphasized aspects of spatial working memory. L-dopa-induced decreases were observed in the right dorsolateral prefrontal cortex during performance of both the planning and the spatial working memory tasks compared with the visuomotor control task. Conversely, L-dopa-induced blood flow increases were observed in the right occipital lobe during the memory task relative to the control task. Data from age-matched healthy volunteers demonstrated that L-dopa effectively normalized blood flow in these regions in the patient group. Moreover, a significant correlation was found between L-dopa-induced, planning related blood flow decreases in the right dorsolateral prefrontal cortex and L-dopa-induced changes in performance on the planning task. These data suggest that L-dopa ameliorates high-level cognitive deficits in Parkinson’s disease by inducing relative blood flow changes in the right dorsolateral prefrontal cortex.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. A. Dockery, R. Hueckel-Weng, N. Birbaumer, and C. Plewnia Enhancement of Planning Ability by Transcranial Direct Current Stimulation J. Neurosci., June 3, 2009; 29(22): 7271 - 7277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Copland, K. L. McMahon, P. A. Silburn, and G. I. de Zubicaray Dopaminergic Neuromodulation of Semantic Processing: A 4-T fMRI Study with Levodopa Cereb Cortex, March 25, 2009; (2009) bhp017v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Dreher, A. Meyer-Lindenberg, P. Kohn, and K. F. Berman From the Cover: Age-related changes in midbrain dopaminergic regulation of the human reward system PNAS, September 30, 2008; 105(39): 15106 - 15111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Rowe, L. Hughes, B. C. P. Ghosh, D. Eckstein, C. H. Williams-Gray, S. Fallon, R. A. Barker, and A. M. Owen Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition Brain, August 1, 2008; 131(8): 2094 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. B. Wisman, G. Sahin, M. Maingay, G. Leanza, and D. Kirik Functional Convergence of Dopaminergic and Cholinergic Input Is Critical for Hippocampus-Dependent Working Memory J. Neurosci., July 30, 2008; 28(31): 7797 - 7807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sawamoto, P. Piccini, G. Hotton, N. Pavese, K. Thielemans, and D. J. Brooks Cognitive deficits and striato-frontal dopamine release in Parkinson's disease Brain, May 1, 2008; 131(5): 1294 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Schott, L. Niehaus, B. C. Wittmann, H. Schutze, C. I. Seidenbecher, H.-J. Heinze, and E. Duzel Ageing and early-stage Parkinson's disease affect separable neural mechanisms of mesolimbic reward processing Brain, September 1, 2007; 130(9): 2412 - 2424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Williams-Gray, A. Hampshire, T. W. Robbins, A. M. Owen, and R. A. Barker Catechol O-Methyltransferase val158met Genotype Influences Frontoparietal Activity during Planning in Patients with Parkinson's Disease J. Neurosci., May 2, 2007; 27(18): 4832 - 4838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Monchi, M. Petrides, B. Mejia-Constain, and A. P. Strafella Cortical activity in Parkinson's disease during executive processing depends on striatal involvement Brain, January 1, 2007; 130(1): 233 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Schott, C. I. Seidenbecher, D. B. Fenker, C. J. Lauer, N. Bunzeck, H.-G. Bernstein, W. Tischmeyer, E. D. Gundelfinger, H.-J. Heinze, and E. Duzel The Dopaminergic Midbrain Participates in Human Episodic Memory Formation: Evidence from Genetic Imaging J. Neurosci., February 1, 2006; 26(5): 1407 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Y. Uc, M. Rizzo, S. W. Anderson, S. Qian, R. L. Rodnitzky, and J. D. Dawson Visual dysfunction in Parkinson disease without dementia Neurology, December 27, 2005; 65(12): 1907 - 1913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A L Cheesman, R A Barker, S J G Lewis, T W Robbins, A M Owen, and D J Brooks Lateralisation of striatal function: evidence from 18F-dopa PET in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, September 1, 2005; 76(9): 1204 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S J G Lewis, T Foltynie, A D Blackwell, T W Robbins, A M Owen, and R A Barker Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(3): 343 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Owen Cognitive Dysfunction in Parkinson's Disease: The Role of Frontostriatal Circuitry Neuroscientist, December 1, 2004; 10(6): 525 - 537. [Abstract] [PDF]
|
|
|
|
 |
|
 D. J. Burn and A. I. Troster Neuropsychiatric Complications of Medical and Surgical Therapies for Parkinson's Disease J Geriatr Psychiatry Neurol, September 1, 2004; 17(3): 172 - 180. [Abstract] [PDF]
|
|
|
|
|
|
T. Foltynie, C. E. G. Brayne, T. W. Robbins, and R. A. Barker The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study Brain, March 1, 2004; 127(3): 550 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Castner and P. S. Goldman-Rakic Enhancement of Working Memory in Aged Monkeys by a Sensitizing Regimen of Dopamine D1 Receptor Stimulation J. Neurosci., February 11, 2004; 24(6): 1446 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Monchi, M. Petrides, J. Doyon, R. B. Postuma, K. Worsley, and A. Dagher Neural Bases of Set-Shifting Deficits in Parkinson's Disease J. Neurosci., January 21, 2004; 24(3): 702 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. K. Goerendt, A. D. Lawrence, and D. J. Brooks Reward Processing in Health and Parkinson's Disease: Neural Organization and Reorganization Cereb Cortex, January 1, 2004; 14(1): 73 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. G. Lewis, A. Dove, T. W. Robbins, R. A. Barker, and A. M. Owen Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in Frontostriatal Neural Circuitry J. Neurosci., July 16, 2003; 23(15): 6351 - 6356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chudasama, C. Baunez, and T. W. Robbins Functional Disconnection of the Medial Prefrontal Cortex and Subthalamic Nucleus in Attentional Performance: Evidence for Corticosubthalamic Interaction J. Neurosci., July 2, 2003; 23(13): 5477 - 5485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Feigin, M. F. Ghilardi, M. Carbon, C. Edwards, M. Fukuda, V. Dhawan, C. Margouleff, C. Ghez, and D. Eidelberg Effects of levodopa on motor sequence learning in Parkinson's disease Neurology, June 10, 2003; 60(11): 1744 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. S. Mattay, T. E. Goldberg, F. Fera, A. R. Hariri, A. Tessitore, M. F. Egan, B. Kolachana, J. H. Callicott, and D. R. Weinberger Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine PNAS, May 13, 2003; 100(10): 6186 - 6191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Escola, Th. Michelet, F. Macia, D. Guehl, B. Bioulac, and P. Burbaud Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia? Brain, January 1, 2003; 126(1): 95 - 114. [Abstract] [Full Text] [PDF]
|
|