Brain, Vol. 125, No. 7, 1646-1659,
July 2002
© 2002 Guarantors of Brain
Neurobehavioural functioning in neonatal intensive care unit graduates in late childhood and early adolescence
1 Institute of Child Development, 2 School of Nursing and 3 Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Correspondence to: C. A. Nelson, University of Minnesota, Institute of Child Development, 51 East River Road, Minneapolis, MN 55455, USA E-mail: canelson{at}tc.umn.edu
The current study examined memory and executive functioning in a sample of children who were hospital ized in a neonatal intensive care unit (NICU) after birth. Thirty-two children born prematurely and/or with medical complications (NICU children) and 25 control children born at term were assessed with the Cambridge Neuropsychological Testing Automated Battery (CANTAB), a multi-dimensional computer-based measure of memory and executive functioning. Comparisons between the NICU and control groups on the CANTAB subscales indicated that the NICU children had a shorter spatial memory span length and committed more forgetting errors on a spatial working memory task. Correlational analyses demonstrated that the number and extent of medical complications at birth was negatively associated with spatial memory span, planning and spatial recognition memory. Multiple regression models suggested that gestational age was of primary importance in predicting spatial memory span, while neurobiological risk was primary in the prediction of spatial working memory errors. Overall, the current results showed fewer deficits in this group of children than were found in a previous neuropsychological assessment of this cohort. The implications of this finding for discerning the effects of neural plasticity over and above normal brain maturational processes are discussed.
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