Brain Advance Access originally published online on August 22, 2003
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Brain, Vol. 126, No. 12, 2597-2608,
December 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg267
Patterning of globus pallidus local field potentials differs between Parkinson’s disease and dystonia
1 Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London and 2 Department of Neurological Surgery, Radcliffe Infirmary, Oxford, UK, 3 Department of Neurology, Charité Campus Virchow, Humboldt University Berlin, Berlin, 4 Department of Neurosurgery and 5 Department of Neurology, University Hospital, Klinikum Mannheim, Mannheim, Germany, 6 Operative Unit of Functional and Stereotactic Neurosurgery and 7 Operative Unit of Neurophysiology, CTO ‘A. Alesini’ Hospital and 8 Institute of Neurology, Università Cattolica, Rome, Italy
Correspondence to: Dr P. Brown, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK. E-mail: p.brown{at}ion.ac.uk
Here we test the hypothesis that there are distinct temporal patterns of synchronized neuronal activity in the pallidum that characterize untreated and treated parkinsonism and dystonia. To this end we recorded local field potentials (LFPs) from the caudal and rostral contact pairs of macroelectrodes implanted into the pallidum of patients for the treatment of Parkinson’s disease (12 cases recorded on and off medication, 17 macroelectrodes) and dystonia (10 cases, 19 macroelectrodes). Percentage LFP power in the 11–30 Hz band was decreased and that in the 4–10 Hz band increased across both contact pairs in treated Parkinson’s disease compared with untreated Parkinson’s disease. Dystonic patients had even less 11–30 Hz power and greater 4–10 Hz power compared with untreated or treated Parkinson’s disease patients. The change in the 4–10 Hz band in patients with dystonia was particularly manifest in the more rostral contact pair, presumed to be within or bridging the globus pallidus externus. We conclude that untreated and treated Parkinson’s disease and dystonia are characterized by different spatiotemporal patterns of activity in the human pallidum.
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