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Brain Advance Access originally published online on August 22, 2003
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Brain, Vol. 126, No. 12, 2667-2681, December 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg277

Gene expression profile of neurodegeneration induced by {alpha}1B-adrenergic receptor overactivity: NMDA/GABAA dysregulation and apoptosis

June Yun1, Robert J. Gaivin1, D. F. McCune1, Attaporn Boongird2, Robert S. Papay1, Zhong Ying2, Pedro J. Gonzalez-Cabrera1, Imad Najm2 and Dianne M. Perez1

1 Department of Molecular Cardiology, Lerner Research Institute and 2 Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH, USA

Correspondence to: Dianne M. Perez, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA E-mail: perezd{at}ccf.org

The {alpha}1-adrenergic receptors ({alpha}1ARs) play an important role in mediating sympathetic neurotransmission in peripheral organ systems; however, central {alpha}1ARs are not well characterized. Additionally, due to the lack of sufficiently subtype-selective drugs or high avidity antibodies, the contribution of each {alpha}1AR subtype to various central functions is currently unclear. Transcription regulation through {alpha}1AR subtypes in the CNS is also unknown. Of interest, transgenic mice that systemically overexpress the {alpha}1BAR show central symptoms that include age-progressive impaired mobility, neurodegeneration and susceptibility to epileptic seizure. To investigate the molecular basis of this phenotype, oligonucleotide microarray studies of whole brains of various ages were carried out to compare gene expression profiles between transgenic and normal brains. The results indicated changes in expression of apoptotic, calcium regulatory, neurodegenerative and genes involved in neurotransmission. Defects in regulation of intracellular calcium are known to play a role in cell death; thus, these genes may provide clues as to the molecular basis of {alpha}1BAR-induced neurodegeneration. Epilepsy is a disorder that can be caused by an imbalance between excitatory (e.g. glutamate) and inhibitory (e.g. GABA) signals. Microarray analysis of transgenic brains showed increased N-methyl-D-aspartate (NMDA) receptors and decreased GABAA, which were confirmed with immunohistochemistry, western blot and radioligand binding studies. The {alpha}1BAR also co-localized with the glutamatergic distribution, suggesting a glutamate imbalance as a molecular rationale for the epileptic seizures.


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