Brain Advance Access originally published online on April 8, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brain, Vol. 126, No. 6, 1392-1408,
June 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg139
Impairment of context-adapted movement selection in a primate model of presymptomatic Parkinson’s disease
Neurologie et Thérapeutique expérimentale (INSERM U289), Hôpital de la Salpêtrière, Paris, France
Correspondence to: Léon Tremblay, INSERM U289, Bâtiment de Pharmacie, 47 boulevard de l’Hôpital, 75651 Paris cedex 13, France E-mail: ltremb{at}ccr.jussieu.fr
The MPTP model allows the presymptomatic stage of parkinsonism to be studied in primates and hence specific behavioural manifestations of moderate nigrostriatal denervation to be identified. On the basis of the physiological literature, we hypothesized that depletion of striatal dopamine could impair the selection of context-relevant habits. To examine this hypothesis, we trained three African green monkeys to perform a simple reach-and-grasp task, including three contexts differing only in terms of the presence and position of transparent obstacles. At the end of training, the analysis of reaching trajectories showed that intact monkeys had built a repertoire of movements, from which they could select the appropriate one depending on the context. In the course of MPTP intoxication (0.3–0.4 mg/kg every 4–5 days) and before parkinsonian motor symptoms appeared, the reaction time (RT), movement time (MT) and variability of reaching trajectories increased in all monkeys. Frequently, the initial direction was not adapted to the context, and consequently the movement was either corrected online or restarted under visual assistance. These non-adapted trajectories appeared to be the main reason for the increase in both RT (because of difficulty in selecting) and MT (because of the need to make corrections). These observations indicate that moderate MPTP-induced dopamine depletion results in a deficit in the selection of context-adapted movement, which is compensated by corrections using either proprioceptive or visual feedback. Similar behavioural disorders might therefore occur in the presymptomatic stage of human Parkinson’s disease.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Worbe, N. Baup, D. Grabli, M. Chaigneau, S. Mounayar, K. McCairn, J. Feger, and L. Tremblay Behavioral and Movement Disorders Induced by Local Inhibitory Dysfunction in Primate Striatum Cereb Cortex, August 1, 2009; 19(8): 1844 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mounayar, S. Boulet, D. Tande, C. Jan, M. Pessiglione, E. C. Hirsch, J. Feger, M. Savasta, C. Francois, and L. Tremblay A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery Brain, November 1, 2007; 130(11): 2898 - 2914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Buhmann, F. Binkofski, C. Klein, C. Buchel, T. van Eimeren, C. Erdmann, K. Hedrich, M. Kasten, J. Hagenah, G. Deuschl, et al. Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism Brain, October 1, 2005; 128(10): 2281 - 2290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pessiglione, D. Guehl, A.-S. Rolland, C. Francois, E. C. Hirsch, J. Feger, and L. Tremblay Thalamic Neuronal Activity in Dopamine-Depleted Primates: Evidence for a Loss of Functional Segregation within Basal Ganglia Circuits J. Neurosci., February 9, 2005; 25(6): 1523 - 1531. [Abstract] [Full Text] [PDF]
|
|