Brain Advance Access originally published online on March 10, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brain, Vol. 127, No. 4, 851-859, 2004
© 2004 Guarantors of Brain
doi: 10.1093/brain/awh100
Cortico-striatal contributions to feedback-based learning: converging data from neuroimaging and neuropsychology
1 Center for Molecular and Behavioral Neuroscience and 2 Department of Psychology, Rutgers University, Newark, 3 Department of Neurology, UMDNJ/Robert Wood Johnson Medical School, New Brunswick, New Jersey, and 4 Department of Psychology, UCLA, Los Angeles, California, USA
Correspondence to: Daphna Shohamy, Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ, USA E-mail: shohamy{at}axon.rutgers.edu
The striatum has been widely implicated in cognition, but a precise understanding of its role remains elusive. Here we present converging evidence for the role of the striatum in feedback-based learning. In a prior functional imaging study, healthy controls showed striatal activity during a feedback-based learning task, which was decreased when the same task was learned without feedback. In the present study, we show that individuals with striatal dysfunction due to Parkinson’s disease are impaired on the feedback-based task, but not on a non-feedback version of the same task. Parkinson’s patients and controls also used different learning strategies depending on feedback structure. This study provides direct behavioural evidence from humans that cortico-striatal systems are necessary for feedback-based learning on a cognitive task. These findings also link between learning impairments in Parkinson’s disease and the physiological and computational evidence for the role of midbrain dopaminergic systems in feedback processing.
Key Words: cognition; learning and memory; basal ganglia; dopamine; Parkinson’s disease
Abbreviations: MMSE= Mini-Mental State Examination; UPDRS = Unified Parkinson’s Disease Rating Scale.
Received July 17, 2003. Revised December 11, 2003. Accepted December 12, 2003.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. F. Rodriguez Stimulus-outcome learnability differentially activates anterior cingulate and hippocampus at feedback processing Learn. Mem., April 29, 2009; 16(5): 324 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Price Distinguishing the contributions of implicit and explicit processes to performance of the weather prediction task Mem Cognit, March 1, 2009; 37(2): 210 - 222. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Klucharev, A. Smidts, and G. Fernandez Brain mechanisms of persuasion: how 'expert power' modulates memory and attitudes Soc Cogn Affect Neurosci, December 1, 2008; 3(4): 353 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Moustafa, M. X. Cohen, S. J. Sherman, and M. J. Frank A Role for Dopamine in Temporal Decision Making and Reward Maximization in Parkinsonism J. Neurosci., November 19, 2008; 28(47): 12294 - 12304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Thomas and K. S. LaBar Fear relevancy, strategy use, and probabilistic learning of cue-outcome associations Learn. Mem., October 2, 2008; 15(10): 777 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Doeller, J. A. King, and N. Burgess Parallel striatal and hippocampal systems for landmarks and boundaries in spatial memory PNAS, April 15, 2008; 105(15): 5915 - 5920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Weiler, C. Bellebaum, and I. Daum Aging affects acquisition and reversal of reward-based associative learning Learn. Mem., April 1, 2008; 15(4): 190 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. SMITH The case for implicit category learning Cogn Affect Behav Neurosci, March 1, 2008; 8(1): 3 - 16. [Abstract] [PDF]
|
|
|
|
 |
|
 C.-H. Lin, K. J Sullivan, A. D Wu, S. Kantak, and C. J Winstein Effect of Task Practice Order on Motor Skill Learning in Adults With Parkinson Disease: A Pilot Study Physical Therapy, September 1, 2007; 87(9): 1120 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. W. Balleine, M. R. Delgado, and O. Hikosaka The Role of the Dorsal Striatum in Reward and Decision-Making J. Neurosci., August 1, 2007; 27(31): 8161 - 8165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Landmann, S. Dehaene, S. Pappata, A. Jobert, M. Bottlaender, D. Roumenov, and D. Le Bihan Dynamics of Prefrontal and Cingulate Activity during a Reward-Based Logical Deduction Task Cereb Cortex, April 1, 2007; 17(4): 749 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Seger and C. M. Cincotta Dynamics of Frontal, Striatal, and Hippocampal Systems during Rule Learning Cereb Cortex, November 1, 2006; 16(11): 1546 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Seger The Basal Ganglia in Human Learning Neuroscientist, August 1, 2006; 12(4): 285 - 290. [Abstract] [PDF]
|
|
|
|
|
|
K. Foerde, B. J. Knowlton, and R. A. Poldrack Modulation of competing memory systems by distraction PNAS, August 1, 2006; 103(31): 11778 - 11783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Seger and C. M. Cincotta The Roles of the Caudate Nucleus in Human Classification Learning J. Neurosci., March 16, 2005; 25(11): 2941 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Frank, L. C. Seeberger, and R. C. O'Reilly By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism Science, December 10, 2004; 306(5703): 1940 - 1943. [Abstract] [Full Text] [PDF]
|
|