Skip Navigation


Brain Advance Access originally published online on February 2, 2005
Brain 2005 128(3):540-549; doi:10.1093/brain/awh406
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
128/3/540    most recent
awh406v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bachelin, C.
Right arrow Articles by Baron-Van Evercooren, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bachelin, C.
Right arrow Articles by Baron-Van Evercooren, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please e-mail: journal.permissions{at}oupjournals.org

Efficient myelin repair in the macaque spinal cord by autologous grafts of Schwann cells

Corinne Bachelin1,*, François Lachapelle1,*, Christelle Girard1, Pierre Moissonnier4, Che Serguera-Lagache2, Jacques Mallet2, Denys Fontaine1, Alexandre Chojnowski3, Eric Le Guern3, Brahim Nait-Oumesmar1 and Anne Baron-Van Evercooren1

1 INSERM U 546, Laboratoire des Affections de la Myéline et des Canaux Ioniques Musculaires, IFRNS 70, 2 CNRS UMR 9923 IFRNS, Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, 3 INSERM U289, Neurologie et Thérapeutique Expérimentale, Paris and 4 ENVA, Maison Alfort, France

Correspondence to: Dr Anne Baron-Van Evercooren, U546 INSERM, CHU Pitié-Salpêtrière, 105 bd de l'Hôpital, 75634 Paris cedex 13. E-mail: baron{at}ccr.jussieu.fr

Experimental transplantation in rodent models of CNS demyelination has led to the idea that Schwann cells may be candidates for cell therapy in human myelin diseases. Here we investigated the ability of Schwann cells autografts to generate myelin in the demyelinated monkey spinal cord. We report that monkey Schwann cells derived from adult peripheral nerve biopsies retain, after growth factor expansion and transduction with a lentiviral vector encoding green fluorescent protein, the ability to differentiate in vitro into promyelinating cells. When transplanted in the demyelinated nude mouse spinal cord, they promoted functional and anatomical repair of the lesions (n = 12). Furthermore, we obtained evidence by immunohistochemistry (n = 2) and electron microscopy (n = 4) that autologous transplantation of expanded monkey Schwann cells in acute lesions of the monkey spinal cord results in the repair of large areas of demyelination; up to 55% of the axons were remyelinated by donor Schwann cells, the remaining ones being remyelinated by oligodendrocytes. Autologous grafts of Schwann cells may thus be of therapeutic value for myelin repair in the adult CNS.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NeuroscientistHome page
V. Zujovic, C. Bachelin, and A. Baron-Van Evercooren
Remyelination of the Central Nervous System: A Valuable Contribution from the Periphery
Neuroscientist, August 1, 2007; 13(4): 383 - 391.
[Abstract] [PDF]

Home page
 BrainHome page
F. Papastefanaki, J. Chen, A. A. Lavdas, D. Thomaidou, M. Schachner, and R. Matsas
Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury
Brain, August 1, 2007; 130(8): 2159 - 2174.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. Levy, H. Ripoche, I. Laurendeau, V. Lazar, N. Ortonne, B. Parfait, K. Leroy, J. Wechsler, I. Salmon, P. Wolkenstein, et al.
Microarray-Based Identification of Tenascin C and Tenascin XB, Genes Possibly Involved in Tumorigenesis Associated with Neurofibromatosis Type 1
Clin. Cancer Res., January 15, 2007; 13(2): 398 - 407.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. A. Black, S. G. Waxman, and K. J. Smith
Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier
Brain, May 1, 2006; 129(5): 1319 - 1329.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Kenoutis, R. C. Efrose, L. Swevers, A. A. Lavdas, M. Gaitanou, R. Matsas, and K. Iatrou
Baculovirus-mediated gene delivery into Mammalian cells does not alter their transcriptional and differentiating potential but is accompanied by early viral gene expression.
J. Virol., April 1, 2006; 80(8): 4135 - 4146.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Girard, A.-P. Bemelmans, N. Dufour, J. Mallet, C. Bachelin, B. Nait-Oumesmar, A. Baron-Van Evercooren, and F. Lachapelle
Grafts of Brain-Derived Neurotrophic Factor and Neurotrophin 3-Transduced Primate Schwann Cells Lead to Functional Recovery of the Demyelinated Mouse Spinal Cord
J. Neurosci., August 31, 2005; 25(35): 7924 - 7933.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.