Skip Navigation


Brain Advance Access originally published online on March 9, 2005
Brain 2005 128(6):1330-1343; doi:10.1093/brain/awh470
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
128/6/1330    most recent
awh470v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bouvard, S.
Right arrow Articles by Ryvlin, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bouvard, S.
Right arrow Articles by Ryvlin, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: a [11C]flumazenil-PET study

Sandrine Bouvard1,2, Nicolas Costes2, Frédéric Bonnefoi2, Franck Lavenne2, François Mauguière1,3, Jacques Delforge4 and Philippe Ryvlin1,2,3

1 EA1880, Federal Institute of Neurosciences, 2 CERMEP and the 3 Department of Functional Neurology and Epileptology, Neurological Hospital, Lyon and 4 CEA, Frédéric Joliot Hospital, Orsay, France

Correspondence to: Professor P. Ryvlin, Service de Neurologie Fonctionnelle et d'Epileptologie, Hôpital Neurologique, 59 Bd Pinel, 69003 Lyon, France E-mail: ryvlin{at}cermep.fr

We have undertaken a test–re-test [11C]flumazenil (FMZ) PET study in 10 drug-resistant epileptic patients, including six with a mesiotemporal epilepsy (MTE), and 10 normal controls, in order to investigate seizure-related short-term plasticity of benzodiazepine (BZD) receptors. All subjects underwent two FMZ-PET scans at a 1 week interval. Patients benefited from a concurrent video-EEG monitoring which allowed determination of the duration of the interictal period (IP) preceding each PET. Test–re-test whole brain B'max variations, evaluated with a partial-saturation injection protocol, were similarly observed in patients and controls, suggesting a physiological modulation of BZD receptors. Five patients (50%), but no controls, also demonstrated clinically significant test–re-test FMZ-PET variations in the mesial temporal region. This was observed in all three patients with MTE and no hippocampal atrophy in whom only the PET study associated with the shortest IP correctly identified the epileptogenic zone. Statistical analysis revealed a significant effect of IP duration on BZD receptor B'max in MTE patients, suggesting that the shorter the IP, the lower the B'max in the epileptogenic hippocampus. FMZ-PET appears to be an interesting tool for investigating both normal and abnormal short-term modulations of the BZD receptor system, and should ideally be performed within a few days following a seizure in patients with MTE and a normal MRI.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
A. Hammers, M.-C. Asselin, R. Hinz, I. Kitchen, D. J. Brooks, J. S. Duncan, and M. J. Koepp
Upregulation of opioid receptor binding following spontaneous epileptic seizures
Brain, April 1, 2007; 130(4): 1009 - 1016.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. Loup, F. Picard, V. M. Andre, P. Kehrli, Y. Yonekawa, H.-G. Wieser, and J.-M. Fritschy
Altered expression of {alpha}3-containing GABAA receptors in the neocortex of patients with focal epilepsy
Brain, December 1, 2006; 129(12): 3277 - 3289.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
R. A. Hurley, R. Fisher, and K. H. Taber
Sudden Onset Panic: Epileptic Aura or Panic Disorder?
J Neuropsychiatry Clin Neurosci, November 1, 2006; 18(4): 436 - 443.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.