Skip Navigation

Brain 2006 129(11):2811-2822; doi:10.1093/brain/awl275
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hodges, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hodges, J. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Review Articles

Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects

John R. Hodges1,2

1 MRC Cognition and Brain Sciences Unit Cambridge, UK 2 Department of Clinical Neurosciences, Addenbrooke's Hospital Cambridge, UK

Correspondence to: Prof. John R. Hodges, MRC-CBU, 15 Chaucer Road, Cambridge CB2 2EF, UK E-mail: john.hodges{at}mrc-cbu.cam.ac.uk

This review commemorates 100 years of research into Alzheimer's disease and, by happy coincidence, the publication of 100 papers in Brain on the topic. The first part of the review traces the evolution of concepts and landmarks in the modern history of Alzheimer's disease. It highlights the continuing role of careful clinico-pathological studies which have set the stage for each major leap forwards, such as the emergence of the cholinergic hypothesis, and the realistation that subjects pass through an amnestic prodrome which is thought to reflect dysfunction of the hippocampal formation before the onset of full blown dementia. The contribution of structural and functional imaging is briefly described. The important contribution of publications in Brain is illustrated throughout the first section. The second part attempts to review the current status of our knowledge concerning behavioural, neuropsychological and neuropsychiatric aspects of the disease, emphasizing areas of continuing controversy.

Key Words: Alzheimer's disease; dementia; memory; semantic memory

Abbreviations: MCI, mild cognitive impairment

Received July 18, 2006. Revised August 31, 2006. Accepted August 31, 2006.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
R. Figueroa, K. Steenland, J. R. MacNeil, A. I. Levey, and I. E. Vega
Geographical Differences in the Occurrence of Alzheimer's Disease Mortality: United States Versus Puerto Rico
American Journal of Alzheimer's Disease and Other Dementias, October 1, 2008; 23(5): 462 - 469.
[Abstract] [PDF]

Home page
 BrainHome page
S. Alladi, J. Xuereb, T. Bak, P. Nestor, J. Knibb, K. Patterson, and J. R. Hodges
Focal cortical presentations of Alzheimer's disease
Brain, October 1, 2007; 130(10): 2636 - 2645.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.