Brain Advance Access originally published online on June 30, 2006
Brain 2006 129(8):2008-2016; doi:10.1093/brain/awl152
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosis
1 Department of Neurological and Behavioral Sciences, University of Siena Italy 2 Department of Neurology, University of Florence Italy 3 Neurology Unit, Hospital of Empoli Italy
Correspondence to: Nicola De Stefano, MD, Neurology and Neurometabolic Unit, Department of Neurological and Behavioral Sciences, University of Siena, Viale Bracci 2, 53100 Siena, Italy E-mail: destefano{at}unisi.it
The trend to start disease-modifying therapy early in the course of multiple sclerosis makes it important to establish whether the benign form is a real entity. In previous studies, measures of magnetization transfer (MT) ratio (MTr) have been shown to provide good estimates of the amount of tissue damage occurring in multiple sclerosis brains. Thus, with the hypothesis that if benign multiple sclerosis patients were really benign, sensitive measures of subtle tissue damage would be less pronounced in these patients than in very early relapsing–remitting (RR) multiple sclerosis patients. We carried out conventional MRI and MT imaging in 50 patients with benign multiple sclerosis [defined as having Kurtzke Expanded Disability Status Score (EDSS) <3 and disease duration >15 years] and in 50 early RR patients selected to have similar disability (EDSS <3) and short disease duration (<3 years). Data were compared with those of 32 demographically-matched normal controls. We used a fully automated procedure to measure lesional-MTr, perilesional-MTr, normal-appearing white matter (NAWM) MTr and cortical-MTr. We found that, after correction for common effects of age, lesional-MTr and perilesional-MTr of benign patients were significantly (P < 0.0001) lower than WM of normal controls, but significantly (P < 0.0001) higher than corresponding tissues of RR patients. In NAWM and cortex, MTr values of benign patients were similar to those of normal controls (P > 0.5) and significantly higher than those of the RR patients (P < 0.0001 and P < 0.01, respectively). Similar differences in MTr measures between benign and RR patients were found when patient groups were selected to have no disability (EDSS 
2) and, for benign multiple sclerosis, very long disease duration (>20 years) or when both groups were matched for high lesion load (T2-weighted lesion volume >10 cm3). We conclude that lesional and non-lesional MTr values can be significantly less pronounced in benign multiple sclerosis than in a cohort of RR patients at their earliest disease stages, suggesting that brain tissue damage is milder in benign multiple sclerosis than in early RR disease. This can be due to an extraordinary beneficial response to demyelination of benign patients and may represent the evidence that benign multiple sclerosis truly exists and might be differentiated from other forms of this illness.
Key Words: multiple sclerosis; benign; magnetization transfer; demyelination; remyelination
Abbreviations: EDSS, Kurtzke Expanded Disability Status Score; GM, grey matter; LV, lesion volume; MTr, magnetization transfer ratio; NAWM, normal-appearing white matter; RR, relapsing–remitting; T1-W, T1-weighted; T2-W, T2-weighted; WM, white matter
Received February 16, 2006. Revised April 10, 2006. Accepted May 11, 2006.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. P. Amato, E. Portaccio, M. L. Stromillo, B. Goretti, V. Zipoli, G. Siracusa, M. Battaglini, A. Giorgio, M. L. Bartolozzi, L. Guidi, et al. Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosis Neurology, August 26, 2008; 71(9): 632 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Rovaris, E Judica, A Ceccarelli, A Ghezzi, V Martinelli, G Comi, and M Filippi Absence of diffuse cervical cord tissue damage in early, non-disabling relapsing-remitting MS: a preliminary study Multiple Sclerosis, July 1, 2008; 14(6): 853 - 856. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Zicari, R. Tassi, M. L. Stromillo, M. Pellegrini, S. Bianchi, G. Cevenini, M. Gistri, N. De Stefano, A. Federico, and M. T. Dotti Right-to-Left Shunt in CADASIL Patients: Prevalence and Correlation With Clinical and MRI Findings Stroke, July 1, 2008; 39(7): 2155 - 2157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hebb, C. Moore, V Bhan, T Campbell, J. Fisk, H. Robertson, M Thorne, E Lacasse, M Holcik, J Gillard, et al. Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination Multiple Sclerosis, June 1, 2008; 14(5): 577 - 594. [Abstract] [PDF]
|
|
|
|
|
|
S. Strasser-Fuchs, C. Enzinger, S. Ropele, M. Wallner, and F. Fazekas Clinically benign multiple sclerosis despite large T2 lesion load: Can we explain this paradox? Multiple Sclerosis, March 1, 2008; 14(2): 205 - 211. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Di Perri, M. Battaglini, M. L. Stromillo, M. L. Bartolozzi, L. Guidi, A. Federico, and N. De Stefano Voxel-Based Assessment of Differences in Damage and Distribution of White Matter Lesions Between Patients With Primary Progressive and Relapsing-Remitting Multiple Sclerosis Arch Neurol, February 1, 2008; 65(2): 236 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Amato, N. De Stefano, H. L. Tremlett, A.-L. Sayao, and V. Devonshire LONGITUDINAL FOLLOW-UP OF "BENIGN" MULTIPLE SCLEROSIS AT 20 YEARS Neurology, August 28, 2007; 69(9): 938 - 939. [Full Text] [PDF]
|
|
|
|
|
|
H. Vrenken, P.J.W. Pouwels, S. Ropele, D.L. Knol, J.J.G. Geurts, C.H. Polman, F. Barkhof, and J.A. Castelijns Magnetization transfer ratio measurement in multiple sclerosis normal-appearing brain tissue: limited differences with controls but relationships with clinical and MR measures of disease Multiple Sclerosis, July 1, 2007; 13(6): 708 - 716. [Abstract] [PDF]
|
|