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Brain Advance Access originally published online on September 26, 2006
Brain 2007 130(1):198-205; doi:10.1093/brain/awl259
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© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Time–frequency analysis reveals decreased high-frequency oscillations in writer's cramp

Zoé Cimatti1,2, Denis P Schwartz3, Frédéric Bourdain4, Sabine Meunier5, Jean-Pierre Bleton6, Marie Vidailhet1,4,7, Bernard Renault2 and Line Garnero2

1 Pierre & Marie Curie University Paris, France 2 Cognitive Neuroscience & Brain Imaging Laboratory Paris, France 3 MEEG Center, Pitié-Salpêtrière Hospital Paris, France 4 Neurology Department, Saint Antoine Hospital Paris, France 5 Physiology and Physiopathology of Motor Control in Humans Laboratory Paris, France 6 Neurology Department, Raymond Garcin Center, Saint Anne Hospital Paris, France 7 Experimental Neurology and Therapeutics Laboratory Paris, France

Correspondence to: Zoe Cimatti, Cognitive Neuroscience, Brain Imaging Laboratory, LENA CNRS-UPR640, 47, Boulevard de l'hôpital, 75651 Paris Cedex 13, France E-mail: cimatti{at}chups.jussieu.fr

High-frequency oscillations (HFO) have been suggested to reflect the activity of thalamocortical and/or intracortical neurons bursting at high frequencies. These circuits seem to be involved in pathophysiological mechanisms of focal dystonia. In healthy subjects, we characterized the spectrotemporal properties of HFO patterns evoked by dominant-hand median-nerve stimulation, using magnetoencephalography coupled with time–frequency analysis. Then, we investigated HFO in patients with writer's cramp and found that HFO patterns are strongly decreased in power and disorganized in time. This supports the assumption that abnormal HFOs reflect pathophysiological mechanisms occurring in focal dystonia, possibly resulting from a dysfunction of somatosensory processing.

Key Words: high-frequency oscillations; dystonia; time–frequency analysis; MEG; somatosensory evoked fields

Abbreviations: HFO, high-frequency oscillations; HFOh, HFO high; HFOl, HFO low; MN, median nerve

Received April 11, 2006. Revised August 16, 2006. Accepted August 18, 2006.


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