Skip Navigation


Brain Advance Access originally published online on August 9, 2007
Brain 2007 130(9):2387-2400; doi:10.1093/brain/awm173
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
130/9/2387    most recent
awm173v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Corlett, P.R.
Right arrow Articles by Fletcher, P.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Corlett, P.R.
Right arrow Articles by Fletcher, P.C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions

P.R. Corlett1, G.K. Murray1,2, G.D. Honey1, M.R.F. Aitken3, D.R. Shanks4, T.W. Robbins3, E.T. Bullmore1,2, A. Dickinson3 and P.C. Fletcher1

1Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, 2CAMEO, Cambridgeshire and Peterborough Mental Health Partnership NHS Trust, Cambridge, CB1 5EE, 3Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, UK and 4Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK

Correspondence to: Dr Paul C. Fletcher, Box 255, University of Cambridge, Department of Psychiatry, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK E-mail: pcf22{at}cam.ac.uk

Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error—a mismatch between expectancy and outcome—drives belief formation, this study examined the possibility that delusions form because of disrupted prediction-error processing. We used fMRI to determine prediction-error-related brain responses in 12 healthy subjects and 12 individuals (7 males) with delusional beliefs. Frontal cortex responses in the patient group were suggestive of disrupted prediction-error processing. Furthermore, across subjects, the extent of disruption was significantly related to an individual's propensity to delusion formation. Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs.

Key Words: prediction error; associative learning; fMRI; delusions; psychosis

Abbreviations: rPFC, right prefrontal cortex

Received February 7, 2007. Accepted July 5, 2007.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
M. J. Frank
Schizophrenia: A Computational Reinforcement Learning Perspective
Schizophr Bull, November 1, 2008; 34(6): 1008 - 1011.
[Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. Yusim,, D. Anbarasan, C. Bernstein, I. Boksay, M. Dulchin, J.-P. Lindenmayer, C. Saavedra-Velez, M. Shapiro, and B. Sadock
Normal Pressure Hydrocephalus Presenting as Othello Syndrome: Case Presentation and Review of the Literature
Am J Psychiatry, September 1, 2008; 165(9): 1119 - 1125.
[Full Text] [PDF]

Home page
 Schizophr BullHome page
J. M. Gold, J. A. Waltz, K. J. Prentice, S. E. Morris, and E. A. Heerey
Reward Processing in Schizophrenia: A Deficit in the Representation of Value
Schizophr Bull, September 1, 2008; 34(5): 835 - 847.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
G. K. Murray, F. Cheng, L. Clark, J. H. Barnett, A. D. Blackwell, P. C. Fletcher, T. W. Robbins, E. T. Bullmore, and P. B. Jones
Reinforcement and Reversal Learning in First-Episode Psychosis
Schizophr Bull, September 1, 2008; 34(5): 848 - 855.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.