Skip Navigation


Brain Advance Access originally published online on May 18, 2008
Brain 2008 131(6):1599-1608; doi:10.1093/brain/awn084
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
131/6/1599    most recent
awn084v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Le Jeune, F.
Right arrow Articles by Vérin, M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Le Jeune, F.
Right arrow Articles by Vérin, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Subthalamic nucleus stimulation affects orbitofrontal cortex in facial emotion recognition: a pet study

F. Le Jeune1,2,*, J. Péron2,3,*, I. Biseul3, S. Fournier2,3, P. Sauleau2,4, S. Drapier2,3, C. Haegelen2,5, D. Drapier2,6, B. Millet2,6, E. Garin1, J.-Y. Herry1, C.-H. Malbert7 and M. Vérin2,3

1Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes, 2Unité de Recherche Universitaire 425 ‘Comportement et Noyaux Gris Centraux’, Université Rennes 1, 3Clinique neurologique, 4Service des Explorations Fonctionnelles, 5Service de Neurochirurgie, Hôpital Pontchaillou, CHU de Rennes, rue Henri Le Guilloux, 35033 Rennes, 6S.H.U. Psychiatrie Adulte, CH Guillaume Régnier, 108 avenue du Général Leclerc, 35703 Rennes and 7UMR SENAH, Ingestive Behaviour Department, 35590 Saint Gilles, France

Correspondence to: Prof. M. Vérin, Service de Neurologie, Hôpital Pontchaillou, CHU de Rennes, rue Henri Le Guilloux, 35033 Rennes, France E-mail: marc.verin{at}chu-rennes.fr

Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and in a recent study, we found fear recognition to be impaired as a result. These changes have been attributed to disturbance of the STN's limbic territory and would appear to confirm that the negative emotion recognition network passes through the STN. In addition, it is now widely acknowledged that damage to the orbitofrontal cortex (OFC), especially the right side, can result in impaired recognition of facial emotions (RFE). In this context, we hypothesized that this reduced recognition of fear is correlated with modifications in the cerebral glucose metabolism of the right OFC. The objective of the present study was first, to reinforce our previous results by demonstrating reduced fear recognition in our Parkinson's disease patient group following STN DBS and, second, to correlate these emotional performances with glucose metabolism using 18FDG-PET. The 18FDG-PET and RFE tasks were both performed by a cohort of 13 Parkinson's disease patients 3 months before and 3 months after surgery for STN DBS. As predicted, we observed a significant reduction in fear recognition following surgery and obtained a positive correlation between these neuropsychological results and changes in glucose metabolism, especially in the right OFC. These results confirm the role of the STN as a key basal ganglia structure in limbic circuits.

Key Words: subthalamic nucleus deep brain stimulation; 18FDG-PET; Parkinson's disease; emotion recognition; orbitofrontal cortex

Abbreviations: DBS, deep brain stimulation; OFC, orbitofrontal cortex; RFE, recognition of facial emotions; SPM, statistical parametric mapping; STN, subthalamic nucleus

.

Received October 31, 2007. Revised February 29, 2008. Accepted April 11, 2008.

*These authors contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.