Brain Advance Access originally published online on January 28, 2009
Brain 2009 132(3):695-708; doi:10.1093/brain/awn347
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Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood
1 Centre de recherche en neuropsychologie et cognition, Canada 2 Département de Kinésiologie, Canada 3 Clinique de Médecine du Sport, Université de Montréal, Montréal, Canada
Correspondence to: Louis De Beaumont, Pavillon Marie-Victorin, Département de Psychologie, Université de Montréal, CP 6128, Succ. Centre-Ville, Montréal, QC, Canada H3C 3J7 E-mail: louis.de.beaumont{at}umontreal.ca
Recent studies have shown that the detrimental effects of sports concussions on cognitive and motor function may persist up to a few years post-injury. The present study sought to investigate the effects of having sustained a sports concussion more than 30 years prior to testing on cognitive and motor functions. Nineteen healthy former athletes, in late adulthood (mean age = 60.79; SD = 5.16), who sustained their last sport-related concussion in early adulthood (mean age = 26.05; SD = 9.21) were compared with 21 healthy former athletes with no history of concussion (mean age = 58.89; SD = 9.07). Neuropsychological tests sensitive to age-related changes in cognition were administered. An auditory oddball paradigm was used to evoke P3a and P3b brain responses. Four TMS paradigms were employed to assess motor cortex excitability: (i) resting motor threshold; (ii) paired-pulse intracortical inhibition and intracortical facilitation; (iii) input/output curve and (iv) cortical silent period (CSP). A rapid alternating movement task was also used to characterize motor system dysfunctions. Relative to controls, former athletes with a history of concussion had: (i) lower performance on neuropsychological tests of episodic memory and response inhibition; (ii) significantly delayed and attenuated P3a/P3b components; (iii) significantly prolonged CSP and (iv) significantly reduced movement velocity (bradykinesia). The finding that the P3, the CSP as well as neuropsychological and motor indices were altered more than three decades post-concussion provides evidence for the chronicity of cognitive and motor system changes consecutive to sports concussion.
Key Words: sports concussion; aging; cognitive dysfunctions; motor cortex inhibition alterations; motor execution slowness; neuropsychology; transcranial magnetic stimulation; rapid alternation movements
Abbreviations: ADHD, attention-deficit hyperactivity disorder; CSP, cortical silent period; ERP, event-related potentials; EEG, electroencephalogram; FDI, first dorsal interosseus; ISI, interstimulus intervals; LED, light-emitting diodes; LOC, loss of consciousness; MCI, mild cognitive impairment; MT, motor threshold; NFT, neurofibrillary tangles; RAM, rapid alternating movement task; RCFT, Rey-Osterrieth Complex Figure Test; TBI, traumatic brain injury; TMS, transcranial magnetic stimulation
Received April 28, 2008. Revised November 17, 2008. Accepted November 26, 2008.
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