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Brain Advance Access originally published online on October 24, 2008
Brain 2009 132(4):1102-1111; doi:10.1093/brain/awn256
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Oskar Fischer and the study of dementia

Michel Goedert

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Correspondence to: Michel Goedert, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK E-mail: mg{at}mrc-lmb.cam.ac.uk

The centenary of Alois Alzheimer's description of the case of Auguste Deter has renewed interest in the early history of dementia research. In his 1907 paper Alzheimer described the presence of plaques and tangles in one case of presenile dementia. In the same year, Oskar Fischer reported neuritic plaques in 12 cases of senile dementia. These were landmark findings in the history of research in dementia because they delineated the clinicopathological entity that is now known as Alzheimer's disease. Although much has been written about Alzheimer, only little is known about Fischer. The present article discusses Fischer's work on dementia in the context of his life and time.

Key Words: Alzheimer; dementia; Fischer; Kraepelin; presbyophrenia

Received August 5, 2008. Revised September 10, 2008. Accepted September 10, 2008.


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