Brain Advance Access published online on July 22, 2003
Brain, doi:10.1093/brain/awg224
© 2003 by Guarantors of Brain
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Article
1 Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
* Corresponding author. E-mail: d.baker{at}ion.ucl.ac.uk.
Received 19 February 2003
; revised 23 April 2003
; accepted 28 April 2003
Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, we demonstrate that the cannabinoid system is neuroprotective during EAE. Mice deficient in the cannabinoid receptor CB1 tolerate inflammatory and excito toxic insults poorly and develop substantial neurodegeneration following immune attack in EAE. In addition, exogenous CB1 agonists can provide significant neuroprotection from the consequences of inflammatory CNS disease in an experimental allergic uveitis model. Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases.
Keywords: cannabinoids; excitotoxicity; experimental allergic encephalomyelitis; multiple sclerosis; neuroprotection
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
2 Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Universite libre de Bruxelles, Brussels, Belgium
3 Neurorehabilitation Group, Institute of Neurology, University College London, Queen Square, London, UK
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