Skip Navigation



Brain Advance Access published online on May 28, 2009
Brain, doi:10.1093/brain/awp132
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
132/8/2058    most recent
awp132v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fouquet, M.
Right arrow Articles by Chételat, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fouquet, M.
Right arrow Articles by Chételat, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease

Marine Fouquet1, Béatrice Desgranges1, Brigitte Landeau1, Edouard Duchesnay2, Florence Mézenge1, Vincent de la Sayette1,3, Fausto Viader1,3, Jean-Claude Baron4, Francis Eustache1 and Gaël Chételat1

1 Inserm - EPHE - Université de Caen/Basse-Normandie, Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France 2 CEA, Laboratoire de Neuroimagerie Assistée par Ordinateur, NeuroSpin, Gif-sur-Yvette, France 3 Département de Neurologie, CHU Côte de Nacre, Caen, France 4 Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

Correspondence to: Gaël Chételat, Laboratoire de Neuropsychologie, Inserm - EPHE - Université de Caen/Basse-Normandie, Unité U923, GIP Cyceron, Bd H Becquerel, 14074 Caen cedex, France E-mail: chetelat{at}cyceron.fr

A sensitive marker for monitoring progression of early Alzheimer's disease would help to develop and test new therapeutic strategies. The present study is aimed at investigating brain metabolism changes over time, as a potential monitoring marker, in patients with amnestic mild cognitive impairment, according to their clinical outcome (converters or non-converters), and in relation to their cognitive decline. Seventeen amnestic mild cognitive impairment patients underwent magnetic resonance imaging and 18FDG-positron emission tomography scans both at inclusion and 18 months later. Baseline and follow-up positron emission tomography data were corrected for partial volume effects and spatially normalized using magnetic resonance imaging data, scaled to the vermis and compared using SPM2. ‘PET-PAC’ maps reflecting metabolic per cent annual changes were created for correlation analyses with cognitive decline. In the whole sample, the greatest metabolic decrease concerned the posterior cingulate-precuneus area. Converters had significantly greater metabolic decrease than non-converters in two ventro-medial prefrontal areas, the subgenual (BA25) and anterior cingulate (BA24/32). PET-PAC in BA25 and BA24/32 combined allowed complete between-group discrimination. BA25 PET-PAC significantly correlated with both cognitive decline and PET-PAC in the hippocampal region and temporal pole, while BA24/32 PET-PAC correlated with posterior cingulate PET-PAC. Finally, the metabolic change in BA8/9/10 was inversely related to that in BA25 and showed relative increase with cognitive decline, suggesting that compensatory processes may occur in this dorso-medial prefrontal region. The observed ventro-medial prefrontal disruption is likely to reflect disconnection from the hippocampus, both indirectly through the cingulum bundle and posterior cingulate cortex for BA24/32, and directly through the uncinate fasciculus for BA25. Altogether, our findings emphasize the potential of 18FDG-positron emission tomography for monitoring early Alzheimer's disease progression.

Key Words: amnestic mild cognitive impairment; 18FDG-PET monitoring; ventro-medial prefrontal cortex; longitudinal study

Abbreviations: aMCI, amnestic mild cognitive impairment; BA, Brodmann areas; 18FDG, 2-[18F]-Fluoro-2-Deoxy-D-Glucose; PAC, per cent annual change; VOI, volume of interest

Received November 5, 2008. Revised March 24, 2009. Accepted April 17, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.