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Brain, Vol. 122, No. 4, 591-592, April 1999
© 1999 Oxford University Press

Editorial

The value of natural history studies of multiple sclerosis

Peter Rudge

Department of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK

Since the description of the natural history of a disease underpins all scientific study of that disease, it is essential that the description is accurate. There have been many publications on the natural history of multiple sclerosis. Initially the databases of patients were derived from a clinical practice of individual clinicians interested in multiple sclerosis, notably McAlpine in the UK and Fog in Scandinavia. Valuable as these studies were they comprised a highly selected group of patients and therefore represented a non-random selection of the total cohort of multiple sclerosis cases. Subsequent studies were . . . [Full Text of this Article]

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M Daumer, L M Griffith, W Meister, R A Nash, and J S Wolinsky
Survival, and time to an advanced disease state or progression, of untreated patients with moderately severe multiple sclerosis in a multicenter observational database: relevance for design of a clinical trial for high dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation
Multiple Sclerosis, April 1, 2006; 12(2): 174 - 179.
[Abstract] [PDF]