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Brain, Vol. 122, No. 6, 1007-1008, June 1999
© 1999 Oxford University Press

Editorial

Hippocampal sclerosis and temporal lobe epilepsy: cause or consequence?

John G. R. Jefferys

Dept of Neurophysiology,University of Birmingham, UK

Hippocampal sclerosis is a very common feature of temporal lobe epilepsy (complex partial seizures or limbic epilepsy). It is found in approximately 50–75% of temporal lobe resections made for medically intractable limbic epilepsy (Honavar and Meldrum, 1997Go); indeed the presence of sclerosis is a good indicator for a positive outcome to surgery. A very long-standing question is whether hippocampal sclerosis is the consequence of repeated seizures, or whether it plays . . . [Full Text of this Article]

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