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Brain, Vol. 123, No. 3, 423-424, March 2000
© 2000 Oxford University Press


Editorial

Unravelling the pathophysiology of calcium channel mutations causing neurological disorders

Bertrand Fontaine and Nacira Tabti

Fédération de Neurologie and INSERM CJF9711, Faculté de Médecine Pitié-Salpêtrière, Paris, France

Voltage-gated calcium channels are molecules that play a key role in cell-to-cell communication and muscle contraction. They are divided into low voltage-activated (LVA or T-type) and high voltage-activated (HVA) channels, which may further be dissected into L, N, P/Q and R channels based on their sensitivity to drugs and toxins. Calcium channels constitute a heteromeric complex composed of a large pore-forming {alpha}1 subunit and four . . . [Full Text of this Article]

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