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Brain, Vol. 125, No. 1, 2-3, January 1, 2002
© 2002 Oxford University Press


Editorial

Obtaining olfactory ensheathing cells from extra-cranial sources a step closer to clinical transplant-mediated repair of the CNS?

Robin J. M. Franklin

University of Cambridge, Cambridge, UK

The extraordinary regenerative properties of the peripheral olfactory system, and the role played by olfactory ensheathing cells (OEC), have been known for many years (Doucette, 1990Go). However, until recently this niche of neurobiology remained relatively obscure, attracting the attention of an enthusiastic, but relatively small band of scientific devotees. The OEC’s sudden rise to prominence has happened because of the recent confluence of the OEC biology tributary with the mainstream of clinically orientated neurobiology, aiming to overcome the regenerative shortcomings of the CNS by cell transplantation. The concept of removing cells from an area that regenerates efficiently and relocating them in one . . . [Full Text of this Article]

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A. Lakatos, P. M. Smith, S. C. Barnett, and R. J. M. Franklin
Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells
Brain, March 1, 2003; 126(3): 598 - 609.
[Abstract] [Full Text] [PDF]