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Brain, Vol. 125, No. 12, 2784-2785, December 2002
© 2002 Oxford University Press

Book Review

PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS

J. Zajicek

Plymouth Postgraduate Medical School, Plymouth, UK

PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS
Edited by M. Filippi and G. Comi
2001. Italy: Springer Verlag
Price £59.50. pp. 128. ISBN 8847001676.

The first 10% of the full text of this article appears below.

The existence of a substantial minority of patients with multiple sclerosis who exhibit an insidious accumulation of disability from the onset of their disease has been recognized since Charcot. Although so-called primary progressive multiple sclerosis (PPMS) may confer a worse prognosis in terms of time to particular disability levels than other forms of the disease, it has often been neglected in terms of general scientific research, and clinical trials in particular. Any all-encompassing hypothesis meant to explain the pathogenesis of multiple sclerosis, must take account of this fascinating group of patients, yet aspects of PPMS are too often considered inconvenient . . . [Full Text of this Article]


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