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Brain, Vol. 125, No. 9, 1935-1936, September 2002
© 2002 Guarantors of Brain

Editorial

Childhood seizures and their consequences for the hippocampus

Richard Grünewald1

1 Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK

The first 10% of the full text of this article appears below.

Both idiopathic generalized epilepsy and focal epilepsy may be associated with seizures in early childhood (Hamati-Haddad and Abou-Khalil, 1998Go). The majority of adults with refractory epilepsy have focal epilepsy, with a temporal lobe epileptic focus in ~60–70% of which hippocampal (mesial temporal) sclerosis is the causative lesion in ~80% (Van Paesschen et al., 1995Go). In newly diagnosed focal epilepsy the prevalence of hippocampal sclerosis is ~11% (Van Paesschen et al., 1998Go). The aetiology of this common cause of focal epilepsy remains enigmatic. One of the few clues is its association with early childhood convulsion (ECC), particularly complicated ECC (usually defined as lasting >15 min, associated with focal neurological deficit . . . [Full Text of this Article]


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