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Brain, Vol. 126, No. 1, 2-4, January 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg001

Editorial

Hunting (auto)immune T cells in neuroimmunological diseases

Reinhard Hohlfeld1

1 Department of Neuroimmunology Max–Planck Institute for Neurobiology Martinsried, Germany

The first 10% of the full text of this article appears below.

In this issue of Brain, a paper by Muraro et al. (2003Go) takes an important step toward improving our ability to detect antigen-specific T cells. To understand better the implications of this advance, it may be helpful to recapitulate some principles of the role of antigen-specific cells in the immune system, focusing in particular on T cell biology. There are two types of antigen-specific immune responses: one is mediated by soluble antibodies secreted by B cells and the other by T lymphocytes. Various established methods of measuring antibodies [e.g. enzyme-linked immunosorbent assays (ELISA), radioimmunoprecipitation assays, western blotting, immunocytochemistry and functional assays] are readily available and of proven value, especially for confirming the diagnosis of autoantibody-mediated neurological diseases like myasthenia gravis, . . . [Full Text of this Article]

Acknowledgement


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