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Brain, Vol. 126, No. 8, 1719-1721, August 2003
© 2003 Guarantors of Brain
doi: 10.1093/brain/awg238

Editorial

A new view of the cortex, new insights into multiple sclerosis

C. Wegner1,2 and P.M. Matthews2,3

Departments of 1 Neuropathology and 2 Clinical Neurology and 3 Centre for Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK

The first 150 words of the full text of this article appear below.

Clinical–pathological correlations have been investigated using magnetic resonance-based techniques in patients with multiple sclerosis arguably more intensively than for any other neurological disease. However, despite impressive accomplishments, consensus regarding a common pathology underlying clinical behaviours in patients with relapsing–remitting (RR), secondary progressive (SP) and primary progressive (PP) multiple sclerosis has been elusive. In part this may have been due to the singular focus on pathological changes in the white matter.

Attention has been directed to the multifocal inflammatory lesions in white matter because their pathology appeared to offer an explanation for the characteristic RR course of the earlier stages of the disease in most patients. However, focal white matter lesions do not lead to disability progression in a simple way, particularly for PP multiple sclerosis, which is characterised by a relatively low white matter lesion load. White matter lesions alone also do not easily explain cognitive dysfunction in multiple sclerosis, . . . [Full Text of this Article]


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