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Brain, Vol. 127, No. 9, 1915-1916, September 2004
© 2004 Guarantors of Brain
doi: 10.1093/brain/awh272

Scientific Commentary

Multiple sclerosis and immune regulatory cells

Jack Antel and Trevor Owens

Montreal Neurologic Institute Canada E-mail: jack.antel@mcgill.ca

The first 10% of the full text of this article appears below.

The multiple sclerosis disease process is defined on the basis of lesions disseminated in space and time within the CNS. Immunization of humans (vaccines) and animals with neural tissue can result in multi-focal CNS inflammatory lesions with demyelination; such disorders are usually uniphasic or self-limited. They are initiated by systemically activated myelin-reactive T cells that then access the CNS. Myelin-reactive T cells can be recovered from the CNS and blood in multiple sclerosis. Such cells can also be recovered from unaffected individuals. These observations raise issues regarding the origin of such cells in non-immunized individuals and why their presence is variably associated with . . . [Full Text of this Article]


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