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Scientific Commentary |
Long-term effects of Deep Brain Stimulation in Parkinson's Disease
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The history of stereotactic neurosurgery for treatment of Parkinson's disease has a remarkable track record. The traditional lesion method, employed and refined over half a century, seemed to have reached its end with the advent of L-dopa medication. But, paradoxically, levodopa-induced motor fluctuations and dyskinesias led to a renaissance of surgical therapy and the introduction of deep brain stimulation by Alim-Louis Benabid et al. (1987)
opened a new therapeutic window for treatment of the late levodopa syndrome. From the beginning it appeared that the effects of stimulation mimic those of stereotactic lesions. Whereas the advantage of the fine tuning of treatment and
Department of Neurology Heinrich-Heine-University Dusseldorf E-mail: freund@neurologie.uni-duesseldorf.de
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