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Brain 2005 128(11):2480-2482; doi:10.1093/brain/awh662
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© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Scientific commentary

The clinical heterogeneity of immune sensory and autonomic neuropathies with (or without) sicca

The first 10% of the full text of this article appears below.

In this issue of Brain, Mori and co-workers from several collaborating Japanese medical schools report on the clinical patterns of neuropathy associated with primary Sjögren's syndrome. The criteria for primary Sjögren's syndrome used were accepted by Japanese and American-European consensus groups: (i) symptoms of dry eyes (keratoconjunctivitis or sicca) or a dry mouth (xerostomia); (ii) objective evidence of keratoconjunctivitis (abnormal Schirmer's or Rose Bengal test) and (iii) evidence of lymphocytic sialoadenitis (e.g. from a lip biopsy) and the presence of antibodies (SS-A or SS-B). Of 92 patients reviewed, mean age ~60 years, there was a strong female preponderance (76 of 92). The following varieties of neuropathy were recognized: sensory ataxia in 36 (39%); sensory painful in 18 (20%); multiple mononeuropathy in 11 (12%); multiple cranial neuropathies in 5 (5%); trigeminal . . . [Full Text of this Article]

Peter James Dyck

The Peripheral Neuropathy Research Laboratory, Mayo Clinic College of Medicine, Rochester, MN


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