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Scientific Commentary |
Trouble on the pitch: are professional football players at increased risk of developing amyotrophic lateral sclerosis?
Department of Clinical Neuroscience, Institute of Psychiatry P041 King's College London SE5 8AF, UK E-mail: nleigh@iop.kcl.ac.uk
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With the exception of some rare familial forms of the disease, the cause of amyotrophic lateral sclerosis (ALS; motor neuron disease) is unknown (Bruijn et al., 2004
). Although 90–95% of ALS cases are apparently sporadic, SOD1 gene mutations with low penetrance (Cudkowicz et al., 1997; Anderson et al., 1997; Shaw et al., 1998; Al-Chalabi et al., 1999; Orrell et al., 1999; Andersen et al., 2003; Majoor-Krakauer et al., 2003; Nogales-Gadea et al., 2004) and other gene variants or mutations may contribute to the population risk (Al-Chalabi et al., 1999; Mitchell, 2000; Lambrechts et al., 2003; Majoor-Krakauer et al., 2003).
Advances in understanding the molecular basis of neurodegenerative diseases point clearly to the importance of genetic factors in conditions that until recently we took to be determined
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  K. Abhinav, A. Al-Chalabi, T. Hortobagyi, and P N. Leigh Electrical injury and amyotrophic lateral sclerosis: a systematic review of the literature J. Neurol. Neurosurg. Psychiatry, May 1, 2007; 78(5): 450 - 453. [Abstract] [Full Text] [PDF]
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