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Scientific Commentaries |
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
University of Pittsburgh Medical School Pittsburgh, MA, USA
E-mail: klunkwe@upmc.edu
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Understanding the natural history of amyloid deposition is of great importance for advancing our knowledge of the pathophysiology of Alzheimer's disease—both during the clinically apparent phase as well as during the antecedent pre-clinical phase (Goldman et al., 2001
). Awareness of the natural history of amyloid deposition also will be necessary to interpret experimental anti-amyloid drug studies that might extend over a year or more. Post-mortem studies cannot, of course, directly assess the progression of amyloid deposition in an individual over time and attempts to deduce the natural history by comparing a series of post-mortem cases with different clinical severities and amyloid loads have significant limitations (Hyman and Gomez-Isla, 1997). Nevertheless, several very extensive post-mortem studies have provided useful information (Braak and Braak, 1997). For example, although some degree of correlation has been reported between plaque load (Cummings et al., 1996) or Aß levels (Naslund
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