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Brain 2006 129(3):561-563; doi:10.1093/brain/awl034
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© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Scientific Commentary

Making progress on the natural history of multiple sclerosis

The first 150 words of the full text of this article appear below.

Typically, the clinical course of multiple sclerosis is characterized by episodes, from which recovery may occur, and by progression. These phases usually evolve in sequence as part of the natural history. The number and frequency of episodes and the interval between first presentation and the often somewhat blurred transition to disease progression are generally held to be rather unpredictable. By definition, progression is not preceded by episodes in individuals with primary progressive multiple sclerosis. At one time, the essential pathological process in multiple sclerosis was thought to be loss of the myelin sheath that normally surrounds axons in the CNS, as a result of local inflammation, from which followed a cascade of secondary events culminating in development of the multifocal sclerotic lesions from which the disease gets its name. Thus, episodes were considered to be the critical component of the disease, and their reduction presented a natural and sufficient target . . . [Full Text of this Article]

Alastair Compston

Department of Clinical Neurosciences University of Cambridge Clinical School, Hills Road, Cambridge, UK


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