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Brain 2007 130(5):1178-1180; doi:10.1093/brain/awm092
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© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Scientific Commentaries

Complexity and heterogeneity in demyelinating disease

Alastair Compston

Department of Clinical Neurosciences
University of Cambridge Clinical School
Cambridge, CB1 2QQ, UK

E-mail: alastair.compston@medschl.cam.ac.uk

The first 150 words of the full text of this article appear below.

In 1894, Eugène Devic (1858–1930) described a 45-year-old female hatter in whom ‘l’autopsie révéla l’existence d’un foyer de myélite aiguë diffuse localisée à la région du renflement lombaire et d’une névrite optique double bien marquée’ ... the autopsy showed a focus of acute diffuse myelitis localized to the lumbar enlargement, as well as a distinct bilateral optic neuritis (Devic, 1894Go). He called the condition ‘neuromyélite optique aigüe’.

Subsequently, it has not proved easy to establish the relationship between neuromyelitis optica and multiple sclerosis. Epidemiological studies performed during the second half of the 20th century show clearly that the typical form of demyelinating disease in Africa, Asia, the Far East and Aboriginal populations is neuromyelitis optica or optic-spinal multiple sclerosis. The relapsing-remitting phenotype, affecting many sites within the brain and spinal cord, is relatively uncommon by comparison with these features of multiple sclerosis in northern Europeans. Until recently, criteria for . . . [Full Text of this Article]


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