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Brain 2008 131(3):604-605; doi:10.1093/brain/awn015
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© The Author (2008). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Scientific Commentary

Neural stem cell-mediated immunomodulation: repairing the haemorrhagic brain

Stefano Pluchino and Gianvito Martino

Gianvito Martino Neuroimmunology Unit – DIBIT and Institute of Experimental Neurology (InSpe) – San Raffaele Scientific Institute, via Olgettina 58, I-20132, Milan, Italy

E-mail: pluchino.stefano@hsr.it

The first 10% of the full text of this article appears below.

Neural stem/precursor cells (NPCs) are broadly proposed as an alternative cell source to repair brain damage upon transplantation. NPC-driven brain repair has variably been shown in several pre-clinical models of neurological disorders. However, a comprehensive knowledge of the different mechanism(s) by which such cells exert their therapeutic potential is still lacking. While the replacement of lost or damaged cells was until a few years ago assumed to be the prime therapeutic mechanism of stem cells, it is now clear that transplanted somatic stem cells may simultaneously instruct several therapeutic mechanisms not confined to cell replacement on its own. Combining the overall therapeutic potential of NPCs in neurological disease, the concept of therapeutic plasticity has recently . . . [Full Text of this Article]


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