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Brain Advance Access originally published online on April 16, 2009
Brain 2009 132(5):1126-1127; doi:10.1093/brain/awp092
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© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Scientific Commentary

Multiple sclerosis and vitamin D: don't (yet) blame it on the sunshine

Graeme Stewart

Westmead Millenium Institute, University of Sydney, Sydney, NSW 2145, Australia. E-mail: graeme_stewart@wmi.usyd.edu.au

The first 10% of the full text of this article appears below.

It is all but 50 years since Sir Donald Acheson proposed a relationship between solar radiation and multiple sclerosis (Acheson et al., 1960Go). The subsequent discovery of the link between sunlight and vitamin D raised the potential for dietary supplementation to prevent or ameliorate the most common chronic neurologic disease of young adults.

Research in the field has proceeded down two distinct lines: epidemiological studies aimed at confirming and refining the association; and studies directed towards providing biological plausibility that may advance association to causation or at least justify large-scale clinical trials with an inexpensive agent. If definitive evidence is represented by a completed jigsaw puzzle, . . . [Full Text of this Article]


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