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Brain 2009 132(6):1413-1416; doi:10.1093/brain/awp140
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© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Evaluation and management of gliomas of the anterior visual pathways, by N. R. Miller, W. J. Iliff and W. R. Green (From the Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA) Brain 1974: 97; 743–754; and The biological and clinical behaviour of pilocytic astrocytomas of the optic pathways, by Adam Borit and Edward P. Richardson Jr (From the CS Kubik Laboratory for Neuropathology of the Department of Pathology and the Neurology service of the Massachusetts General Hospital, the Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, and the Departments of Neurology-Neuropathology, Ophthalmology and Pathology, Harvard Medical School, Boston, MA, USA) Brain 1982: 105; 161–187.

Alastair Compston

Cambridge

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The first 150 words of the full text of this article appear below.

The dilemma is this: ‘once regarded as neoplasms needing as complete excision as possible, gliomas of the optic nerve are now thought to be benign lesions, diagnosed neuroradiologically and [in which] neither surgical nor radiotherapeutic intervention is warranted’. By way of answer, Neil Miller and colleagues review the experience of the Wilmer Eye Hospital from 1930 to 1973. Multiple sources of identification have identified 51 cases, with complete ascertainment of the previous records and follow-up of all patients still living in 1972–73. Forty tumours are biopsy proven (but with occasional amendment following reinterpretation of the original neuropathology reports) of which 29 (73%) involve the chiasm as well as the optic nerve; the remaining cases are included on the basis of neuroradiology and findings at craniotomy.

The chiasmal lesions, most commonly affecting boys, tend to present in childhood (24 of 29 aged <13 years, and median age at presentation 4 years) . . . [Full Text of this Article]


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Related articles in Brain:

EVALUATION AND MANAGEMENT OF GLIOMAS OF THE ANTERIOR VISUAL PATHWAYS
N. R. MILLER, W. J. ILIFF, and W. R. GREEN
Brain 1974 97: 743-754. [PDF]  

THE BIOLOGICAL AND CLINICAL BEHAVIOUR OF PILOCYTIC ASTROCYTOMAS OF THE OPTIC PATHWAYS
ADAM BORIT and EDWARD P. RICHARDSON, JR
Brain 1982 105: 161-187. [PDF]