Table 2 Whole and regional brain volumes (traced manually) in people with Asperger’s syndrome and healthy controls
| Brain structure |
Asperger’s |
Control |
F |
P |
|
(n = 21) |
(n = 24) |
(d.f. = 39) |
|
| Hemispheres |
| % Intracranial volume |
| Total |
74.92 (2.85) |
75.61 (2.71) |
0.03 |
0.87 |
| Left |
37.27 (1.41) |
37.40 (1.36) |
1.18 |
0.28 |
| Right |
37.23 (1.33) |
37.87 (1.25) |
1.89 |
0.18 |
| Raw volume (ml) |
| Total |
1084 (127) |
1105 (118) |
1.49 |
0.23 |
| Left |
539 (61) |
547 (59) |
0.02 |
0.90 |
| Right |
539 (64) |
544 (60) |
0.04 |
0.84 |
| Frontal lobe |
|
|
|
|
| % Intracranial volume |
| Total |
36.60 (3.03) |
37.68 (1.72) |
0.08 |
0.78 |
| Left |
18.36 (1.92) |
18.59 (0.87) |
0.02 |
0.87 |
| Right |
18.29 (1.56) |
18.87 (1.11) |
0.02 |
0.88 |
| Raw volume (ml) |
| Total |
529 (72) |
550 (61) |
0.08 |
0.78 |
| Left |
266 (46) |
271 (29) |
0.11 |
0.74 |
| Right |
265 (37) |
276 (34) |
0.09 |
0.77 |
| Temporal lobe |
| % Intracranial volume |
| Total |
8.71 (1.02) |
10.74 (5.83) |
2.65 |
0.11 |
| Left |
4.24 (0.56) |
5.16 (2.87) |
1.99 |
0.17 |
| Right |
4.46 (0.53) |
5.56 (2.88) |
3.37 |
0.07 |
| Raw volume (ml) |
| Total |
126 (20) |
156 (77) |
2.48 |
0.12 |
| Left |
62 (11) |
75 (38) |
1.77 |
0.19 |
| Right |
64 (10) |
81 (38) |
3.25 |
0.08 |
| Parietal lobe |
|
|
|
|
| % Intracranial volume |
|
|
|
|
| Total |
20.02 (2.27) |
18.16 (2.68) |
0.17 |
0.68 |
| Left |
9.96 (1.08) |
9.06 (1.40) |
0.36 |
0.55 |
| Right |
9.94 (1.16) |
9.08 (1.29) |
0.11 |
0.74 |
| Raw volume (ml) |
|
|
|
|
| Total |
290 (46) |
266 (49) |
0.08 |
0.78 |
| Left |
144 (21) |
132 (25) |
0.19 |
0.66 |
| Right |
144 (24) |
133 (24) |
0.04 |
0.84 |
| Occipital lobe |
|
|
|
|
| % Intracranial volume |
| Total |
9.63 (1.97) |
10.26 (2.51) |
0.46 |
0.50 |
| Left |
4.99 (1.12) |
5.30 (1.28) |
1.23 |
0.27 |
| Right |
4.57 (1.01) |
4.92 (1.34) |
0.04 |
0.84 |
| Raw volume (ml) |
| Total |
139 (33) |
150 (38) |
0.26 |
0.62 |
| Left |
72 (17) |
77 (20) |
1.23 |
0.27 |
| Right |
66 (18) |
72 (20) |
0.04 |
0.84 |
| Caudate nucleus |
| % Intracranial volume |
|
|
|
|
| Total |
0.60 (0.08) |
0.61(0.06) |
1.49 |
0.23 |
| Left |
0.30 (0.04) |
0.31 (0.03) |
1.40 |
0.24 |
| Right |
0.30 (0.04) |
0.30 (0.03) |
1.36 |
0.25 |
| Raw volume (ml) |
| Total |
8.67 (0.98) |
8.76(1.0) |
0.62 |
0.44 |
| Left |
4.31 (0.47) |
4.53(0.67) |
0.67 |
0.42 |
| Right |
4.40 (0.53) |
4.32(0.61) |
0.51 |
0.48 |
| Putamen nucleus |
| % Intracranial volume |
| Total |
0.53 (0.09) |
0.56 (0.07) |
0.03 |
0.86 |
| Left |
0.26 (0.05) |
0.28 (0.04) |
0.001 |
0.97 |
| Right |
0.27 (0.04) |
0.28 (0.04) |
0.15 |
0.70 |
| Raw volume (ml) |
|
|
|
|
| Total |
7.60 (1.36) |
8.22 (1.25) |
0.005 |
0.94 |
| Left |
3.76 (0.73) |
4.12 (0.64) |
0.02 |
0.90 |
| Right |
3.84 (0.67) |
4.09 (0.65) |
0.08 |
0.79 |
| Lateral ventricles |
|
|
|
|
| % Intracranial volume |
|
|
|
|
| Total |
1.60 (1.67) |
1.12 (0.38) |
0.05 |
0.83 |
| Left |
0.88 (1.11) |
0.54 (0.20) |
0.05 |
0.83 |
| Right |
0.82 (0.98) |
0.57 (0.22) |
0.01 |
0.92 |
| Raw volume (ml) |
|
|
|
|
| Total |
24 (29) |
16 (6) |
0.02 |
0.88 |
| Left |
13.83 (20.56) |
7.94 (3.01) |
0.03 |
0.87 |
| Right |
12.76 (17.64) |
8.30 (3.39) |
0.003 |
0.96 |
| Cerebellum |
|
|
|
|
| % Intracranial volume |
|
|
|
|
| Total |
9.06 (1.36) |
9.25 (0.84) |
2.24 |
0.14 |
| Raw volume (ml) |
|
|
|
|
| Total |
130 (19) |
135 (15) |
1.49 |
0.23 |
| Total cranial volume |
1448 (172) |
1460 (127) |
0.04 |
0.85 |
| |
Values are group means (standard deviation). Percentage volumes shown are expressed as a percentage of total cranial volume.
